112778-71-9

Upstream product

• 934-32-7 1H-benzimidazol-2-amine 
• 112778-94-6 (E)-3-Dimethylamino-3-phenyl-1-p-tolyl-propenone 
• 4224-87-7 4-methyl-chalcone 
• 122-00-9 para-methylacetophenone 
• 19429-87-9 α,α-diethoxy-N,N-dimethylbenzenemethanamine 
• 4224-96-8 3-phenyl-1-p-tolylprop-2-en-1-one 
• 29540-87-2 1,2-diaminobenzimidazole 
• 126827-45-0 2-Phenyl-4-p-tolyl-1,4-dihydro-benzo[4,5]imidazo[1,2-a]pyrimidine 

Relevant academic research and scientific papers

An efficient and green synthesis of benzo[4,5]imidazo[1,2-a]pyrimidines using highly active and stable poly acrylic acid-supported layered double hydroxides

A facile and efficient method for the synthesis of benzo[4,5]imidazo[1,2-a]pyrimidines has been achieved via highly active and reusable heterogeneous poly acrylic acid-supported layered double hydroxides (PAA-g-LDHs) catalyst promoted one-pot reaction of 1H-benzo[d]imidazol-2-amine, with α,β-unsaturated carbonyl compounds under solvent-free conditions. PAA-g-LDHs catalyst was successfully synthesized via reversible addition-fragmentation chain-transfer polymerization using grafting reaction and was characterized by different analytical techniques. The significant features of this reaction include expedient one-pot process, short reaction time, excellent yields, wide substrate scope and operational simplicity. Also, the catalyst could be reused for several consecutive runs without any apparent loss in its catalytic activity.

CYCLOCONDENSATIONS OF CHALCONES WITH 2-AMINO- AND 1,2-DIAMINOBENZIMIDAZOLES

2,4-Diaryl-1,4-dihydropyrimidobenzimidazoles were obtained by the reaction of 2-aminobenzimidazole with chalcones, and their heteroaromatization was accomplished.The condensation of 1,2-diaminobenzimidazole with unsymmetrically substituted chalcones, which leads to substituted pyrimidobenzimidazoles, was studied.The specificity of this reaction was ascertained by means of alternative synthesis.

A Simple Regioselective Synthesis of Pyrimidobenzimidazoles

2-Aminobenzimidazoles were reacted with enaminones in acetic acid to give pyrimidobenzimidazoles.With a substituted enaminone only one regioisomer was obtained.Structural assignments based on nmr and uv spectroscopy are presented.Possible pathways