112799-19-6

Basic information

• Product Name: 4-(piperidin-1-yl)tetrahydro-2H-pyran-4-carbonitrile
• Synonyms: 4-(piperidin-1-yl)tetrahydro-2H-pyran-4-carbonitrile;4-(piperidin-1-yl)oxane-4-carbonitrile;Tetrahydro-4-(1-piperidinyl)-2H-pyran-4-carbonitrile
• CAS NO: 112799-19-6
• Molecular Formula: C₁₁H₁₈N₂O
• Molecular Weight: 194.27342
• Mol File: 112799-19-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 49℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(piperidin-1-yl)tetrahydro-2H-pyran-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(piperidin-1-yl)tetrahydro-2H-pyran-4-carbonitrile(112799-19-6)
• EPA Substance Registry System: 4-(piperidin-1-yl)tetrahydro-2H-pyran-4-carbonitrile(112799-19-6)

Safety Data

• Hazardous Substances Data: 112799-19-6(Hazardous Substances Data)

Usage

General Description

4-(piperidin-1-yl)tetrahydro-2H-pyran-4-carbonitrile is a chemical compound with the molecular formula C11H16N2O. It is a heterocyclic organic compound that contains a piperidine ring and a tetrahydropyran ring. The carbonitrile group signifies the presence of a carbon atom triple-bonded to a nitrogen atom. 4-(piperidin-1-yl)tetrahydro-2H-pyran-4-carbonitrile may have potential applications in pharmaceutical and medicinal chemistry due to its unique structure and properties. Its synthesis and characterization may also be of interest to researchers in the field of organic chemistry.

Upstream product

• 110-89-4 piperidine 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 151-50-8 potassium cyanide 
• 112799-02-7 4-Trimethylsilanyloxy-tetrahydro-pyran-4-carbonitrile 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 50289-10-6 4-hydroxy-tetrahydropyran-4-carbonitrile 

Relevant articles and documents

The low affinity PCP sites in the rat cerebellum not only bind TCP-like but also BTCP-like structures

Congeners of the potent dopamine (DA) re-uptake inhibitor l-[1-(2- benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP) are unexpectedly able to bind in the rat cerebellum, although this structure is devoid of dopaminergic nerve endings. In line with previous studies the hypothesis that they bind to low affinity PCP sites labelled with [3H]TCP in the rat cerebellum, even though they do not bind to the high affinity PCP sites in the forebrain, was considered. Analogues of l-[1-(2-thiophenyl)cyclohexyl]piperidine (TCP) and BTCP with a modified aromatic moiety and with O or S atoms substituted in the cyclohexyl ring were prepared and tested in competition experiments both in rat forebrain and cerebellum membranes labelled with [3H]TCP, and in rat striatum membranes labelled with [3H]BTCP. Results indicated that BTCP and congeners could bind to low affinity PCP sites labelled with [3H]TCP in the rat cerebellum with a decrease of the selectivity for the DA transporter. On the contrary, some TCP analogues displayed a very high selectivity for these low affinity sites: they might be important pharmacological tools to elucidate the nature and function at yet unknown of these sites. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Effect of lowered lipophilicity on the affinity of PCP analogues for the PCP receptor and the dopamine transporter

Oxygen and sulphur atoms were introduced in the cyclohexyl and piperidinyl moieties of the basic structures 1-(1-phenyl-cyclohexyl)piperidine (PCP), 1- [1-(2-thienyl)cyclohexyl]piperidine (TCP), and 1-[1-(2- benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP) to lower their global lipophilicity. The compounds obtained were tested comparatively for their affinity for the PCP receptor labelled with [3H]TCP and for the dopamine (DA) transporter labelled with [3H]BTCP. Lowering the global lipophilicity in PCP and TCP series is detrimental to the affinity and selectivity for the PCP receptor. In the BTCP series lowering of the global lipophilicity is less deleterious and may, on the contrary, be a useful way of increasing selectivity for the DA transporter in some instances.