1128-91-2Relevant academic research and scientific papers
Using N-substituted-2-amino-4,6-dimethoxypyrimidines in the synthesis of aliphatic guanidines
Shaw, Julian W.,Barbance, Laure,Grayson, David H.,Rozas, Isabel
, p. 4990 - 4992 (2015)
Abstract The use of 2-chloro-4,6-dimethoxypyrimdine as a tool for the syntheses of substituted guanidines is presented. This method, that we had previously shown to be very useful for aromatic amines, introduces an atom economical, cost effective and environmentally safe method for the installation of the guanidine functionality in aliphatic primary and secondary amines.
GUANIDINE COMPOUNDS AND USE THEREOF
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Page/Page column 72; 81; 82, (2015/11/09)
The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.
INHIBITION OF CELL PROLIFERATION
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Page/Page column 47; 59; 73, (2008/06/13)
The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.
