112806-17-4

Basic information

• Product Name: (5Z)-3-[(2-chlorophenyl)carbonyl]-5-[(3-chlorophenyl)methylidene]-2-thioxoimidazolidin-4-one
• CAS NO: 112806-17-4
• Molecular Formula: C₁₇H₁₀Cl₂N₂O₂S
• Molecular Weight: 377.2445
• Mol File: 112806-17-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 525.4°C at 760 mmHg
• Flash Point: 271.6°C
• Density: 1.56g/cm³
• Vapor Pressure: 3.92E-11mmHg at 25°C
• Refractive Index: 1.733
• CAS DataBase Reference: (5Z)-3-[(2-chlorophenyl)carbonyl]-5-[(3-chlorophenyl)methylidene]-2-thioxoimidazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5Z)-3-[(2-chlorophenyl)carbonyl]-5-[(3-chlorophenyl)methylidene]-2-thioxoimidazolidin-4-one(112806-17-4)
• EPA Substance Registry System: (5Z)-3-[(2-chlorophenyl)carbonyl]-5-[(3-chlorophenyl)methylidene]-2-thioxoimidazolidin-4-one(112806-17-4)

Safety Data

• Hazardous Substances Data: 112806-17-4(Hazardous Substances Data)

Usage

General Description

(5Z)-3-[(2-chlorophenyl)carbonyl]-5-[(3-chlorophenyl)methylidene]-2-thioxoimidazolidin-4-one is a chemical compound with the molecular formula C15H10Cl2N2O2S. (5Z)-3-[(2-chlorophenyl)carbonyl]-5-[(3-chlorophenyl)methylidene]-2-thioxoimidazolidin-4-one belongs to the class of thioxoimidazolidin-4-one derivatives and contains both chlorophenyl and carbonyl groups in its structure. It is a potent and selective non-peptide antagonist of the endothelin ETA receptor, making it a potential therapeutic agent for the treatment of cardiovascular diseases like pulmonary arterial hypertension and heart failure. Additionally, its properties as a competitive antagonist of the endothelin receptor also make it a valuable research tool for studying the pathophysiological role of endothelin receptors in various disease states.