1128075-60-4Relevant academic research and scientific papers
Palladium-Catalyzed Regioselective C?H Arylation of 4-Azaindazole at C3, C5 and C7 Positions
Faarasse, Soukaina,El Kazzouli, Sa?d,Bourzikat, Otmane,Bourg, Stéphane,Aci-Sèche, Samia,Bonnet, Pascal,Suzenet, Franck,Guillaumet, Gérald
, p. 3937 - 3945 (2021)
Direct and site-selective C5 and C7 palladium-catalyzed C?H arylations of 4-azaindazole N-oxide have been achieved. A bidentate ligand and Pd(OAc)2 catalyst in toluene promoted the activation of C5 position, while a phosphine ligand and PdCl2 catalyst in DMA directed the arylation at C7 position. Using this new method, the synthesis of C5, C7-diarylated 4-azaindazole N-oxides as well as the C3, C5, C7-triarylated 4-azaindazoles was achieved towards future medicinal compounds development. (Figure presented.).
Site-selective azaindole arylation at the azine and azole rings via N-oxide activation
Huestis, Malcolm P.,Fagnou, Keith
supporting information; experimental part, p. 1357 - 1360 (2009/09/05)
Subjection of N-methyl 6-and 7-azaindole N-oxides to a Pd(OAc) 2/DavePhos catalyst system enables regioselective direct arylation of the azine ring. Following deoxygenation, 7-azaindole substrates undergo an additional regioselective azole direct arylation event in good yield.
