112822-86-3Relevant academic research and scientific papers
The preparation of two, preclinical amino-quinazolinediones as antibacterial agents
Beylin, Vladimir,Boyles, David C.,Curran, Timothy T.,Macikenas, Dainius,Parlett IV, Roger V.,Vrieze, Derek
, p. 441 - 449 (2007)
This paper describes the synthesis of two amino-quinazolinediones which are potent gyrase/topoisomerase inhibitors and useful as antibacterial agents. The early scale-up work to prepare a chiral side chain on multigram scale and two different amino-quinaz
Synthesis and bioactivity of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives
Wang, Teng,Dong, Ying,Wang, Li-Chen,Chen, Zhen
, p. 641 - 646 (2008/03/11)
A series of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives was prepared and examined for cardiotonic activity. The structures of these new pyridazinone derivatives were confirmed by IR, 1H-NMR and mass spectrum. The cardiotonic activities of these compounds were studied on isolated perfused toad heart and compared with the activity of levosimendan (CAS 141505-33-1). Compound 5a emerged as the most interesting compound in this series with potential cardiotonic activity. ECV Editio Cantor Verlag.
Quinolonecarboxylic acid derivatives and their preparation
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, (2008/06/13)
Quinolonecarboxylic acid derivatives of the following formula, STR1 wherein R indicates straight or branched lower alkyl, R1 indicates cycloalkyl having 3 to 6 carbon atoms, straight or branched lower alkyl, halogenoalkyl, alkenyl, hydroxyalkyl
