112849-15-7

Basic information

• Product Name: (2-Cyclopropyl-2-oxoethyl)triphenyl-phosphoniuM BroMide
• Synonyms: (2-Cyclopropyl-2-oxoethyl)triphenyl-phosphoniuM BroMide
• CAS NO: 112849-15-7
• Molecular Formula: Br*C₂₃H₂₂OP
• Molecular Weight: 425.297941
• Product Categories: Miscellaneous Reagents
• Mol File: 112849-15-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Solubility: Methanol, Water
• CAS DataBase Reference: (2-Cyclopropyl-2-oxoethyl)triphenyl-phosphoniuM BroMide(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Cyclopropyl-2-oxoethyl)triphenyl-phosphoniuM BroMide(112849-15-7)
• EPA Substance Registry System: (2-Cyclopropyl-2-oxoethyl)triphenyl-phosphoniuM BroMide(112849-15-7)

Safety Data

• Hazardous Substances Data: 112849-15-7(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Reactant in the preparation of Vitamin D2 (V676040) derivatives.

Upstream product

• 69267-75-0 2-bromo-1-cyclopropylethan-1-one 
• 603-35-0 triphenylphosphine 
• 765-43-5 Cyclopropyl methyl ketone 

Downstream Products

• 688328-34-9 E-3-(3-bromothiophen-2-yl)1-cyclopropylpropenone 
• 599197-55-4 (E)-3-(2-bromophenyl)-1-cyclopropylprop-2-en-1-one 
• 115540-29-9 (1S,3R,1'R,2'R,3'S)-(3'-cyclopropyl-1',2'-epoxy-3'-hydroxypropyl)-9,10-secopregna-5(E),7(E),10⁽¹⁹⁾-triene 
• 115540-29-9 (1S,3R,1'R,2'R,3'R)-(3'-cyclopropyl-1',2'-epoxy-3'-hydroxypropyl)-9,10-secopregna-5(E),7(E),10⁽¹⁹⁾-triene 
• 115540-29-9 (1S,3R,1'S,2'S,3'S)-(3'-cyclopropyl-1',2'-epoxy-3'-hydroxypropyl)-9,10-secopregna-5(E),7(E),10⁽¹⁹⁾-triene 
• 115540-29-9 (1S,3R,1'S,2'S,3'R)-(3'-cyclopropyl-1',2'-epoxy-3'-hydroxypropyl)-9,10-secopregna-5(E),7(E),10⁽¹⁹⁾-triene 
• 115648-68-5 (1S,3R,20S)-bis(tert-butyldimethylsilyloxy)-20-(3'-cyclopropyl-3'-oxyprop-1'(E)-enyl)-9,10-secopregna-5(E),7(E),10⁽¹⁹⁾-triene 
• 112849-17-9 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3’-cyclopropyl-3’-oxypropyl-1’(E)-enyl)-9,10-secopregna-5(E),7(E),10(19)-triene 
• 112849-27-1 (1S,3R,3'S)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(E),7(E),10⁽¹⁹⁾-triene 
• 112875-61-3 (1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10⁽¹⁹⁾-triene 
• 112849-26-0 (1S,3R,3'R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(E),7(E),10⁽¹⁹⁾-triene 
• 112910-41-5 (1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(R)-cycloprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10⁽¹⁹⁾-triene 
• 112965-21-6 calcipotriene 
• 112827-99-3 20(R)-(3'(R)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-1(S),3(R)-dihydroxy-9,10-secopregna-5(Z),7(E),10⁽¹⁹⁾-triene 

Relevant articles and documents

A Ba/Pd Catalytic System Enables Dehydrative Cross-Coupling and Excellent E-Selective Wittig Reactions

A Ba/Pd cooperative catalysis system was developed to enable the dehydrative cross-coupling of allylic alcohols with P-ylides to occur directly and promote a subsequent Wittig reaction in one pot. A variety of multisubstituted 1,4-dienes were isolated in good to excellent yields with broad P-ylides (stabilized by both ester and ketone carbonyl groups) and aldehyde (aliphatic and aromatic) substrates with excellent E selectivity.

Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy

An efficient strategy for the one-pot synthesis of polysubstituted pyridines via a cascade reaction from aldehydes, phosphorus ylides, and propargyl azide is reported. The reaction sequence involves a Wittig reaction, a Staudinger reaction, an aza-Wittig reaction, a 6π-3-azatriene electrocyclization, and a 1,3-H shift. This protocol provides quick access to the polysubstituted pyridines from readily available substrates in good to excellent yields.

Synthesis of MC 903, a biologically active vitamin D metabolite analogue

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