112856-44-7

Basic information

• Product Name: Losigamone
• Synonyms: Losigamone;losigame;5-[(2-Chlorophenyl)hydroxymethyl]-4-methoxyfuran-2(5H)-one;Losigamon
• CAS NO: 112856-44-7
• Molecular Formula: C12H11ClO4
• Molecular Weight: 254.668
• Mol File: 112856-44-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 480.1°Cat760mmHg
• Flash Point: 244.1°C
• Appearance: /
• Density: 1.39g/cm³
• Vapor Pressure: 5.01E-10mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: Losigamone(CAS DataBase Reference)
• NIST Chemistry Reference: Losigamone(112856-44-7)
• EPA Substance Registry System: Losigamone(112856-44-7)

Safety Data

• Hazardous Substances Data: 112856-44-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H11ClO4/c1-16-9-6-10(14)17-12(9)11(15)7-4-2-3-5-8(7)13/h2-6,11-12,15H,1H3/t11-,12-/m0/s1

Related news

Interactions between two enantiomers of Losigamone (cas 112856-44-7) and conventional antiepileptic drugs in the mouse maximal electroshock model — An isobolographic analysis08/01/2019

The aim of this study was the isobolographic evaluation of interactions between two enantiomers of losigamone, AO-242 [(+)-5(R)-α(S)-5-(2-chlorophenylhydroxymethyl)-4-methoxy-2(5H)-furanone] and AO-294 [(-)-5(S)-α(R)-5-(2-chlorophenylhydroxymethyl)-4-methoxy-2(5H)-furanone], and valproate, car...detailed

Isobolographic analysis of interactions between Losigamone (cas 112856-44-7) and conventional antiepileptic drugs in the mouse maximal electroshock model07/31/2019

The aim of this study was the isobolographic evaluation of interactions between losigamone (LSG), valproate (VPA), carbamazepine (CBZ), phenytoin (PHT), and phenobarbital (PB) in the maximal electroshock (MES) test in mice. Electroconvulsions were produced by means of an alternating current (ear...detailed

Effects of XE991, retigabine, Losigamone (cas 112856-44-7) and ZD7288 on kainate-induced theta-like and gamma network oscillations in the rat hippocampus in vitro07/29/2019

Ion currents such as M-currents (IM), persistent sodium currents (INaP) and H-currents (Ih) have been observed in a variety of brain regions, including the hippocampal formation, where storage and retrieval of information are facilitated by oscillatory network activities. They have been suggeste...detailed

Effects of Losigamone (cas 112856-44-7) on synaptic potentials and spike frequency habituation in rat entorhinal cortex and hippocarnpal CA1 neurones07/28/2019

Losigamone is an anticonvulsant both in vivo and in vitro. We here studied possible mechanisms for such effects with conventional intracellular recordings from pyramidal cells of area CA1 and entorhinal cortex in combined hippocampal-entorhinal cortex slices. Losigamone reversibly reduced the nu...detailed

Losigamone (cas 112856-44-7) a putative antiepileptic drug07/27/2019

Losigamone (LSG) has shown anticonvulsant efficacy and low neurotoxicity in preclinical testing and has been tolerated in Phase I clinical trials. We report an open-label, add-on tolerability study of six ascending LSG dosage levels from 600 to 2,100 mg daily in patients receiving phenytoin (PHT...detailed

Losigamone (cas 112856-44-7) decreases spontaneous synaptic activity in cultured hippocampal neurons07/26/2019

Losigamone is a new antiepileptic drug with an unknown mechanism of action. Here we report on the effects of losigamone on the synaptic activity in a network of cultured rat hippocampal neurons. Losigamone dose dependently reduced the frequency of spontaneous synaptic events without affecting th...detailed

Efficacy and safety of Losigamone (cas 112856-44-7) in partial seizures: a randomized double-blind study07/25/2019

The objective of the study was to investigate the efficacy and safety of two different dosages of Losigamone (LSG) in add-on treatment of partial seizures. In a multi-center, double-blind, randomized clinical trial, patients received one of three 12-week treatments: placebo, LSG 1200 mg/day, or ...detailed

The antiepileptic drug Losigamone (cas 112856-44-7) decreases the persistent Na+ current in rat hippocampal neurons07/24/2019

The tetronic acid derivative losigamone is a new anticonvulsant drug with a mechanism of action that was previously unknown. The drug decreases the frequency of spontaneous action potentials and suppresses repetitive firing of neurons. Here we tested the hypothesis that losigamone suppresses the...detailed