112898-15-4

Basic information

• Product Name: 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT
• Synonyms: BENZOYLBENZOIC ADENOSINE 5'-TRIPHOSPHATE;2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT;2'-3'-O-(4-benzoylbenzoyl)adenosine*5'-triphospha;2'-3'-O-(4-BENZOYLBENZOYL)ADENOSINE5'-TR IPHOSPHATE;2'(3')-o-(4-benzoylbenzoyl)adenosine 5'-triphosphate triethylammonium salt;benzoylbenzoyl-atp;benzoylbenzoyl-ATP triethylammonium salt, mixed isomers;Benzoylbenzoyl-ATP, Bz-ATP
• CAS NO: 112898-15-4
• Molecular Formula: C30H39N6O15P3
• Molecular Weight: 816.58
• Mol File: 112898-15-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• Solubility: ≤14 mg/ml in DMSO
• CAS DataBase Reference: 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT(112898-15-4)
• EPA Substance Registry System: 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT(112898-15-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 112898-15-4(Hazardous Substances Data)

Usage

Uses

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt has been used as a P2X4 receptor agonist in rat kidney sections, type I diabetes induced rats and astrocyte?neuron coculture. It has also been used as a synthetic ATP analog in isotonic E3 medium.

General Description

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate is a photoreactive analog of ATP.

Biological Activity

Prototypic P2X 7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC 50 = 0.7 μ M in HEK 293 cells). Exhibits partial agonist activity at P2X 1 (pEC 50 = 8.7) and P2Y 1 receptors and can be used as a photoaffinity label for ATPase.

Biochem/physiol Actions

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt is a selective purinergic receptor (P2X) agonist. It is more potent than ATP at homodimeric P2X7 receptors. It also effectively activates P2X1, P2X2, and P2X3 receptors. Useful as a photoaffinity label for proteins and enzymes that bind ATP.