1129-68-6Relevant academic research and scientific papers
Dealkenylative Alkenylation: Formal σ-Bond Metathesis of Olefins
Kwon, Ohyun,Sadykhov, Gusein,Swain, Manisha,Wang, Ruoxi
, p. 17565 - 17571 (2020)
The dealkenylative alkenylation of alkene C(sp3)?C(sp2) bonds has been an unexplored area for C?C bond formation. Herein 64 examples of β-alkylated styrene derivatives, synthesized through the reactions of readily accessible feedstock olefins with β-nitrostyrenes by ozone/FeII-mediated radical substitutions, are reported. These reactions proceed with good efficiencies and high stereoselectivities under mild reaction conditions and tolerate an array of functional groups. Also demonstrated is the applicability of the strategy through several synthetic transformations of the products, as well as the syntheses of the natural product iso-moracin and the drug (E)-metanicotine.
Radiosynthesis and PET studies of [11C]RJR-2403, a nicotinic agonist
Studenov, Andrei R.,Wegner, Adam M.,Ding, Yu-Shin
, p. 425 - 436 (2001)
(E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine (RJR-2403, or metanicotine), a nicotinic agonist developed as a cognitive-enhancing drug for Alzheimer's disease, was labeled with carbon-11 using [11C]methyl iodide via a simple and efficient one-step procedure. Regioselectivity of [11C]methylation on the aliphatic nitrogen versus pyridine nitrogen is strongly dependent on the reaction solvent. The reaction in acetonitrile exclusively yields aliphatic N-[11C-methyl]alkylation ([11C]RJR-2403), while only a byproduct is formed when DMF is used as a solvent. Positron emission tomographic (PET) studies in baboon showed a homogeneous distribution of radioactivity within baboon brain with a slow clearance. [11C]RJR-2403 was metabolized very rapidly as evidenced by the fact that at 2 min after intravenous injection only 50% of the total carbon-11 in plasma is parent compound. Copyright
