112913-99-2

Basic information

• Product Name: C-(4-PHENYL-MORPHOLIN-2-YL)-METHYLAMINE
• Synonyms: C-(4-PHENYL-MORPHOLIN-2-YL)-METHYLAMINE;(4-phenylMorpholin-2-yl)MethanaMine;4-phenyl-2-Morpholinemethanamine
• CAS NO: 112913-99-2
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.26
• Mol File: 112913-99-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 331.9±27.0 °C(Predicted)
• Appearance: /
• Density: 1.083±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.37±0.29(Predicted)
• CAS DataBase Reference: C-(4-PHENYL-MORPHOLIN-2-YL)-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: C-(4-PHENYL-MORPHOLIN-2-YL)-METHYLAMINE(112913-99-2)
• EPA Substance Registry System: C-(4-PHENYL-MORPHOLIN-2-YL)-METHYLAMINE(112913-99-2)

Safety Data

• Hazardous Substances Data: 112913-99-2(Hazardous Substances Data)

Usage

General Description

C-(4-phenyl-morpholin-2-yl)-methylamine is a chemical compound with the molecular formula C14H19N2O. It is a type of organic amine derivative, and its structure consists of a central morpholine ring with a phenyl group attached at the 4-position and a methylamine group attached to the central carbon atom. C-(4-PHENYL-MORPHOLIN-2-YL)-METHYLAMINE is commonly used in the pharmaceutical industry as a building block for the synthesis of various bioactive compounds and drug molecules. Its chemical structure and reactivity make it suitable for creating new drug candidates and developing potential therapeutic agents for various medical conditions. Additionally, it also has potential applications in other fields such as chemical research and the development of new materials.

Upstream product

• 112913-98-1 2-chloromethyl-4-phenyl-morpholine 
• 122-98-5 2-Anilinoethanol 

Relevant articles and documents

Novel benzamides as selective and potent gastrokinetic agents. III. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-methoxy- and 2-ethoxy-N-[(4-substituted 2-morpholinyl)methyl]-benzamides

A series of 4-amino-5-chloro-2-methoxy- and 2-ethoxy-N-[(4-substituted 2-morpholinyl)methyl]benzamides (11-44) were prepared and evaluated for gastrokinetic activity by determining their effects on the gastric emptying of phenol red semisolid meal in rats. The N-4 substituent includes alkyl, phenoxyalkyl, (4-fluorobenzoyl)alkyl, and heteroarylmethyl groups. The benzamide derivatives, having an isopropyl, isoamyl, neopentyl, 3-(4-chlorophenoxy)propyl, or pyridylmethyl group at N-4, showed potent in vivo gastric emptying activity. In particular, 4-amino-5-chloro-2-ethoxy-N-[[4-(3-pyridylmethyl)-2-morpholinyl]methyl ]benzamide (57b) was equipotent to the 4-fluorobenzyl analogue 1b (AS-4370 as its citrate) in the gastrokinetic activity on phenol red semisolid meal in rats and mice, and on resin pellet solid meal in rats. Moreover, compound 57b was free from dopamine D2 receptor antagonistic activity in both in vitro ([3H]spiperone binding) and in vivo (apomorphine-induced emesis in dogs) tests. Structure-activity relationships of compounds with various substituents at N-4 are also discussed.