112920-15-7Relevant academic research and scientific papers
SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF
-
Page/Page column 134, (2011/09/20)
This invention provides compounds of formula (I): wherein ring A, X1, X2, X3, R2, R4b, R10, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
Alkyliron and Alkylcobalt Reagents, VIII. - Alkyl-Iron(II) Compounds as Reagents and Catalysts for the Transformation of Acyl Chlorides into Ketones
Kauffmann, Thomas,Voss, Karl-Uwe,Neiteler, Gabriele
, p. 1453 - 1460 (2007/10/02)
Me2Fe, Bu2Fe, Me3FeLi, or Bu3FeLi - prepared in situ by reduction of FeCl3 to FeCl2 and subsequent alkylation with MeLi, MeMgBr, BuLi, or BuMgBr - are useful reagents for the conversion of acyl chlorides into ketones.The system (RMgX + catalytic amount of FeCl3) react like the FeII reagents with acyl chlorides to give ketones even at -65 deg C.Competition experiments with benzoyl chloride/2-methoxybenzoyl chloride show that the selectivity increases (competition constants Kk = 9.9, 10.7, 10.9, 15.0, ca. 110) in the sequence MeFeCl, Me2Fe, Me3Fe(MgBr), Me4Fe(MgBr)2, and catalytic system (MeMgBr + 2.5 mol percent FeCl3) (= 2, 3, 4, 5, and 40MeMgBr per 1 FeCl3, respectively).A new hypothesis on the nature of the active catalyst is discussed. Key Words: Organoiron compounds / Iron catalysts / Ketone synthesis
Synthesis of (+/-)-Sydonic Acid
Murali, D.,Rao, G. S. Krishna
, p. 156 - 157 (2007/10/02)
A two-step synthesis of sydonic acid (1) makes use of the phenolic acetylbenzoic acid (4) obtained by the regio-selective oxidation of the known 2-acetoxy-4-methylacetophenone (3) by benzyltriethylammonium permanganate (BTAP).Similar BTAP oxidation of the
