112921-04-7Relevant articles and documents
Solid-phase synthesis of 5'-O-[N-(Acyl)sulfamoyl]adenosine derivatives
Redwan, Itedale Namro,Ingemyr, Hanna Jacobson,Ljungdahl, Thomas,Lawson, Christopher P.,Graotli, Morten
experimental part, p. 3665 - 3669 (2012/08/13)
The solid-phase synthesis of 5'-O-[N-(acyl)sulfamoyl]adenosine derivatives is described. The use of a Rink amide polystyrene solid support together with an appropriately protected ribo-purine starting material allowed for the development of a highly reliable and practical route for the solid-phase synthesis of 5'-O-[N-(acyl)sulfamoyl]adenosines. The developed procedure enables the efficient parallel synthesis of the target compounds in high yields. These compounds are non-hydrolysable isosteres of acyl-adenylates, which play an important role in a range of different metabolic pathways such as ribosomal and non-ribosomal peptide synthesis, fatty acid oxidation or enzyme regulation; some adenylate-forming enzymes are potential drug targets.
Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules
Cisar, Justin S.,Ferreras, Julian A.,Soni, Rajesh K.,Quadri, Luis E. N.,Tan, Derek S.
, p. 7752 - 7753 (2008/02/08)
Macrocyclic aminoacyl-AMP analogs have been developed to inhibit non-ribosomal peptide synthetase amino acid adenylation domains selectively by mimicking a cisoid ligand binding conformation observed in crystal structures. In contrast, these macrocycles d
