112925-36-7

Basic information

• Product Name: 1-(4-benzyl-1,4-oxazepan-2-yl)methanamine(SALTDATA: FREE)
• Synonyms: [(4-benzyl-1,4-oxazepan-2-yl)methyl]amine;[4-(benzyl)-1,4-oxazepan-2-yl]methylamine;[4-(phenylmethyl)-1,4-oxazepan-2-yl]methanamine;MFCD11108419;1-(4-benzyl-1,4-oxazepan-2-yl)methanamine(SALTDATA: FREE);1-(4-benzyl-1,4-oxazepan-2-yl)methanamine(SALTDATA
• CAS NO: 112925-36-7
• Molecular Formula: C₁₃H₂₀N₂O
• Molecular Weight: 220.32
• Mol File: 112925-36-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 331.3±27.0 °C(Predicted)
• Appearance: /
• Density: 1.052±0.06 g/cm3(Predicted)
• PKA: 9.37±0.29(Predicted)
• CAS DataBase Reference: 1-(4-benzyl-1,4-oxazepan-2-yl)methanamine(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-benzyl-1,4-oxazepan-2-yl)methanamine(SALTDATA: FREE)(112925-36-7)
• EPA Substance Registry System: 1-(4-benzyl-1,4-oxazepan-2-yl)methanamine(SALTDATA: FREE)(112925-36-7)

Safety Data

• Hazardous Substances Data: 112925-36-7(Hazardous Substances Data)

Usage

General Description

1-(4-benzyl-1,4-oxazepan-2-yl)methanamine is a chemical compound with the molecular formula C15H20N2O and a molecular weight of 244.33 g/mol. It is a member of the class of compounds known as benzylamines, which are organic compounds containing an amine group attached to a benzyl group. 1-(4-benzyl-1,4-oxazepan-2-yl)methanamine(SALTDATA: FREE) is also known as SALTDATA: FREE. It has a 1,4-oxazepan-2-yl group attached to the amine group, giving it a cyclic structure. This chemical may have various applications in pharmaceuticals, as a reagent in organic synthesis, or in other industrial processes. However, the specific uses and properties of this compound would depend on its salt form and any accompanying data.

Upstream product

• 309747-68-0 3-[Benzyl-(3-chloro-2-hydroxy-propyl)-amino]-propan-1-ol 
• 129482-45-7 4-benzyl-2-chloromethyl-[1,4]oxazepane 
• 4720-29-0 3-(benzylamino)propan-1-ol 
• 129482-46-8 4-benzyl-2-(phthalimidomethyl)hexahydro-1,4-oxazepine 

Downstream Products

• 1184662-16-5 2-acetylaminomethyl-4-benzyl-1,4-hexahydroxazepine 

Relevant articles and documents

Development of potent serotonin-3 (5-HT3) receptor antagonists. I. Structure-activity relationships of 2-alkoxy-4-amino-5-chlorobenzamide derivatives

A new series of 2-alkoxy-4-amino-5-chlorobenzamide derivatives hearing five- to seven-membered heteroalicyclic rings in the amine moiety was synthesized and evaluated for serotonin-3 (5-HT3) receptor antagonistic activity by assaying the ability to antagonize the yon Bezold-Jarisch reflex in rats. The five- to seven-membered heteroalicycles comprise pyrrolidine, morpholine, 1,4-thiazine, piperidine, piperazine, 1,4-oxazepine, 1,4- thiazepine, azepine, and 1,4-diazepine rings. Among them, some benzamide derivatives having a 1,4-diazepine ring showed a potent 5-HT3 receptor antagonistic activity. In particular, 4-amino-5-chloro-N-(1,4- dimethylhexahydro-1H-1,4-diazepin-6-yl)-2-ethoxyhenzamide (96) and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 103 showed potent 5-HT3 receptor antagonistic activity without 5-HT4 receptor binding affinity.

Substituted benzamide derivatives, for enhancing gastrointestinal motility

Compounds of the formula: STR1 wherein R is hydrogen, alkoxycarbonyl, benzyloxycarbonyl, heteroarylalkyl, phenylalkenyl, or --T--(Y)p --R6 (wherein T is single bond or alkylene, Y is oxygen, sulfur or carbonyl, R6 is phenyl, substituted phenyl, naphthyl, or diphenylmethyl, and p is 0 or 1, provided that when T is single bond, p is 0); R1 is halogen, hydroxy, alkoxy, cycloalkyloxy, alkenyloxy, alkynyloxy, alkoxy interrupted by oxygen or carbonyl, alkylthio, amino, monosubstituted amino, or a substituted alkoxy; R2 is hydrogen; R3 is hydrogen, halogen, amino, alkylamino, dialkylamino, alkanoylamino, or nitro; R4 is hydrogen, halogen, nitro, sulfamoyl, alkylsulfamoyl, or dialkylsulfamoyl; or any two adjacent groups of the R1, R2, R3 and R4 may combine to form alkylenedioxy, and the remaining two groups are each hydrogen; R5 is hydrogen or alkyl; X is alkylene; m and n are each 1 or 2; provided that at least one of the groups R2, R3 and R4 is other than hydrogen, and acid addition salts, quaternary ammonium salts and N-oxide derivatives thereof, processes for preparation thereof, and pharmaceutical composition containing the same. Said compounds, salts and N-oxide derivatives thereof show excellent gastrointestinal motility enhancing activity.