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112926-02-0

INDO 1-AM is a cell-permeable derivative of INDO 1, which is a fluorescent probe used for detecting calcium ions (Ca2+). It is a yellow solid that exhibits a large shift in fluorescent emission from 482 nm to 398 nm upon binding with Ca2+. INDO 1-AM has a lower affinity for Ca2+ compared to FURA-2 but is still a valuable tool for various applications due to its cell permeability and rapid hydrolysis by cytoplasmic esterases into the membrane-impermeant INDO 1.

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  • 1H-Indole-6-carboxylicacid,2-[4-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-3-[2-[2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]phenyl]-,(acetyloxy)methyl ester

    Cas No: 112926-02-0

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  • 1H-Indole-6-carboxylicacid,2-[4-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-3-[2-[2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]phenyl]-,(acetyloxy)methyl ester

    Cas No: 112926-02-0

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  • 1H-Indole-6-carboxylicacid,2-[4-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-3-[2-[2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]phenyl]-,(acetyloxy)methyl ester

    Cas No: 112926-02-0

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  • 1H-Indole-6-carboxylicacid,2-[4-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-3-[2-[2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]phenyl]-,(acetyloxy)methyl ester

    Cas No: 112926-02-0

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  • 112926-02-0 Structure

  • Basic information

    1. Product Name: INDO 1-AM
    2. Synonyms: indo-1pentaacetoxymethylester;INDO 1-AM;1-[2-AMINO-5-(6-CARBOXYINDOL-2-YL)PHENOXY]-2-(2'-AMINO-5'-METHYLPHENOXY) ETHANE-N,N,N',N'-TETRAACETIC ACID PENTAACETOXYMETHYL ESTER;1-[2-AMINO-5-(6-CARBOXYINDOL-2-YL)PHENOXY]-2-(2'-AMINO-5'-METHYLPHENOXY) ETHANE-N,N,N,N-TETRAACETIC ACID PENTAACETOXY-METHYL ESTER;4-(6-CARBOXY-2-INDOLYL)-4'-METHYL-2,2'-(ETHYLENEDIOXY)DIANILINE-N,N,N',N'-TETRAACETIC ACID TETRAKIS(ACETOXYMETHYL) ESTER;ACETOXYMETHYL ESTER OF INDO 1;INDO 1/AM (1SET = 10x100UG);INDO 1-AM >93% FLUORESCENT MARKER FO
    3. CAS NO:112926-02-0
    4. Molecular Formula: C47H51N3O22
    5. Molecular Weight: 1009.91
    6. EINECS: N/A
    7. Product Categories: Indole
    8. Mol File: 112926-02-0.mol

  • Chemical Properties

    1. Melting Point: >250 ℃
    2. Boiling Point: 1009.2 °C at 760 mmHg
    3. Flash Point: 564.1 °C
    4. Appearance: Light yellow/powder
    5. Density: 1.374g/cm3
    6. Vapor Pressure: 3.2E-28mmHg at 25°C
    7. Refractive Index: 1.577
    8. Storage Temp.: 2-8°C
    9. Solubility: DMSO: soluble
    10. PKA: 14.85±0.30(Predicted)
    11. CAS DataBase Reference: INDO 1-AM(CAS DataBase Reference)
    12. NIST Chemistry Reference: INDO 1-AM(112926-02-0)
    13. EPA Substance Registry System: INDO 1-AM(112926-02-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: 22-24/25
    4. WGK Germany: 3
    5. RTECS:
    6. F: 8-10
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 112926-02-0(Hazardous Substances Data)

112926-02-0 Usage

Uses

Used in Biomedical Research:
INDO 1-AM is used as a cell-permeable fluorescent probe for detecting and measuring intracellular calcium ions (Ca2+) in biomedical research. The application reason is its ability to cross cell membranes and be rapidly hydrolyzed by cytoplasmic esterases into the membrane-impermeant INDO 1, allowing for ratiometric fluorescence measurements.
Used in Neuroscience:
In neuroscience, INDO 1-AM is used as a fluorescent probe for studying calcium signaling in neurons and other excitable cells. The application reason is its sensitivity to changes in intracellular calcium levels, which play a crucial role in various neuronal processes, including neurotransmitter release, synaptic plasticity, and neuronal development.
Used in Cell Biology:
In cell biology, INDO 1-AM is used as a tool for investigating calcium signaling pathways and their role in cell function and dysfunction. The application reason is its ability to provide real-time measurements of intracellular calcium levels, which are essential for various cellular processes such as cell proliferation, differentiation, and apoptosis.
Used in Drug Discovery:
INDO 1-AM is used as a screening tool in drug discovery for identifying compounds that modulate calcium signaling pathways. The application reason is its ability to detect changes in intracellular calcium levels, which can be indicative of the effects of potential drug candidates on cellular processes involving calcium ions.

Check Digit Verification of cas no

The CAS Registry Mumber 112926-02-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,9,2 and 6 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 112926-02:
(8*1)+(7*1)+(6*2)+(5*9)+(4*2)+(3*6)+(2*0)+(1*2)=100
100 % 10 = 0
So 112926-02-0 is a valid CAS Registry Number.
InChI:InChI=1/C33H34N2O17/c1-19(36)45-15-49-30(40)12-35(13-31(41)50-16-46-20(2)37)28-8-7-24(11-29(28)44-14-32(42)51-17-47-21(3)38)26-9-23-5-6-25(10-27(23)34-26)33(43)52-18-48-22(4)39/h5-11,34H,12-18H2,1-4H3

112926-02-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name acetyloxymethyl 2-[4-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-3-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]phenyl]-1H-indole-6-carboxylate

1.2 Other means of identification

Product number -
Other names INDO 1/AM

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:112926-02-0 SDS

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