112929-89-2

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-Bromo-1-methylnaphthalene is used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals for its ability to contribute to the development of new and effective chemical entities.
Used in Dye and Pigment Production:
3-Bromo-1-methylnaphthalene is employed as a chemical intermediate in the production of dyes and pigments, where its unique properties contribute to the creation of vibrant and stable colorants for various applications.
Safety and Environmental Considerations:
3-Bromo-1-methylnaphthalene is toxic if inhaled, swallowed, or comes into contact with the skin, and may cause respiratory irritation upon inhalation. It is also harmful to aquatic life with long-lasting effects. Therefore, it is crucial to handle and dispose of this chemical with extreme caution to minimize environmental and health risks.

Upstream product

• 4523-46-0 4-methyl-2-naphthalenamine 
• 112929-88-1 1-amino-2-bromo-4-methylnaphthalene 
• 4523-45-9 1-amino-4-methylnaphthalene 
• 51670-78-1 1-acetamido-4-methylnaphthalene 

Downstream Products

• 112929-90-5 3-cyano-1-methylnaphthalene 
• 303779-66-0 3-bromo-1-naphthaldehyde 
• 303063-43-6 (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(4-methoxy-benzyloxy)-5-(4-methyl-naphthalen-2-yl)-tetrahydro-furan 

Relevant academic research and scientific papers

Pyrrole derivatives useful for farnesyl transferase inhibitors and their preparations

The present invention relates to a novel pyrrole derivative which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof; to a process for preparation of said compound; and to a pharmaceutical composition such as anti-cancer composition, etc. comprising said compound as an active ingredient together with pharmaceutically acceptable carrier.

Preparation of biaryl compounds

A method for the preparation of biaryl compounds is disclosed which comprises contacting an aryl halide under conditions suitable to form a Grignard reagent and thereafter contacting the Grignard reagent with an aryl chloride in the presence of a catalyst comprising a nickel compound and a coordinating ligand under conditions suitable for the formation of biaryl compound. In an alternate embodiment of the present invention, biaryl compounds are prepared directly from aryl halides in a single reaction vessel by contacting aryl halide with elemental magnesium and a nickel catalyst comprising a nickel compound and a coordinating ligand in an aprotic, non-polar, ether-containing solvent system for a time and under conditions suitable for the formation of biaryl compound.

Preparation of biaryl compounds

A method for the preparation of biaryl compounds is disclosed which comprises contacting an aryl halide with a tertiary-alkyl organometallic reagent (or the precursor components thereof) in the presence of a catalyst comprising a nickel compound and a coordinating ligand under conditions suitable for the formation of biaryl compound. In an alternative embodiment of the present invention, nickel(0) compounds are prepared from nickel(II) compounds by contacting a nickel(II) compound with a combination of an organophosphine and a bidentate nitrogen-containing coordinating ligand, and a tertiary-alkyl organometallic reagent (or the precursor components thereof) in an aprotic, non-polar, ether-containing solvent system for a time and under conditions suitable for the formation of nickel(0) compound.

Preparation of biaryl compounds

A method for the preparation of biaryl compounds is disclosed which comprises contacting an aromatic halide in the presence of a catalyst comprising zerovalent nickel, a bidentate phosphorus-containing coordinating ligand and a reducing metal in a polar, aprotic solvent system for a time and under conditions suitable for the formation of biaryl compound.

Substituent effects on homolytic versus heterolytic photocleavage of (1-naphthylmethyl)trimethylammonium chlorides

Singlet escited state rate constants have been measured for both the heterolytic and homolytic photocleavage of 3- and 4-methoxy and 3- and 4-cyano (1-naphthylmethyl)trimethylammonium chlorides, 6-10.The results are interpreted in terms of the meta effect or changes in charge distribution upon excitation and the competition between bond cleavage, electron transfer, and hydrogen atom transfer in the contact pairs resulting from the two types of cleavage.