112935-92-9Relevant articles and documents
Preparation method of bambuterol impurity B
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, (2017/02/09)
The invention discloses a preparation method of a bambuterol impurity B. The method comprises the following steps: 1. by using 3,5-dihydroxyacetophenone as an initial raw material, completely reacting in the presence of DMF (N,N-dimethylformamide), K2CO3 and N,N-dimethyl formyl chloride at 80 DEG C, filtering, concentrating, and carrying out column chromatography to obtain yellow oil, thereby preparing a compound I; 2. by using the compound I as a substrate, carrying out reflux reaction in the presence of SeO2, dioxane and water, thereby preparing a compound II; and 3. treating the compound II, EtOH and NaBH4 in an ice bath, and reacting at room temperature, thereby preparing a compound III. According to the scheme, the common solvent is adopted for treatment in combination with greenness and environment friendliness; and the ethyl acetate safe solvent is utilized to prepare the bambuterol impurity B. Thus, the technique is easy to operate, has the advantages of low energy consumption and high product purity, and has favorable market application value.