1129407-45-9Relevant academic research and scientific papers
Synthesis of amphidinolide e C10-C26 fragment
Esteban, Jorge,Costa, Anna M.,Vilarrasa, Jaume
experimental part, p. 4843 - 4846 (2009/05/31)
(Equation Presented) The key C10-C26 fragment in a total synthesis of (-)-amphidinolide E has been prepared from an oxolane-containing C10-C17 segment (9, derived from L-glutamic acid) via a Julia-Kocienski reaction with aldehyde 3, followed by a Sharpless AD to obtain the desired diol. The C22-C26 fragment was installed by means of an efficient Suzuki-Molander coupling, with an organotrifluoroborate reagent (4, arising from a cross-metathesis reaction between a vinylboronate and 2-methyl-1,4-pentadiene).
