112944-94-2Relevant articles and documents
Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities
Chung, Po-Yee,Gambari, Roberto,Chen, Yi-Xin,Cheng, Chor-Hing,Bian, Zhao-Xiang,Chan, Albert Sun-Chi,Tang, Johnny Cheuk-On,Leung, Polly Hang-Mei,Chui, Chung-Hin,Lam, Kim-Hung
, p. 1568 - 1577 (2015/04/27)
A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.
