112945-01-4Relevant academic research and scientific papers
Synthesis of aryl ethers via a sulfonyl transfer reaction
Sach, Neal W.,Richter, Daniel T.,Cripps, Stephan,Tran-Dubé, Michelle,Zhu, Huichun,Huang, Buwen,Cui, Jean,Sutton, Scott C.
scheme or table, p. 3886 - 3889 (2012/09/22)
A general synthesis of aryl ethers from primary and secondary alcohols and aryl mesylates is presented. The reaction proceeds via a sulfonyl-transfer mechanism. In this paper, we compare the sulfonyl transfer reaction to Mitsunobu ether formation. The reaction can be employed in a multistep synthesis where the aryl mesylate is used as a phenol protecting group and then as an activating group for ether formation. This protecting/activating group strategy is demonstrated using raloxifene as the target.
