112946-34-6Relevant articles and documents
Free-Radical Cyclizations: Application to the Total Synthesis of dl-Pleurotin and dl-Dihydropleurotin Acid
Hart, David J.,Huang, Horng-Chih,Krishnamurthy, Ram,Schwartz, Theresa
, p. 7507 - 7519 (2007/10/02)
Total syntheses of the antitumor antibiotic pleurotin (1) and dihydropleurotin acid (2) are described.Early stages of the synthesis feature the construction of a trans perhydroindan substructure using a stereoselective free-radical cyclization, and the final stage of the synthesis involves the biomimetic conversion of dihydropleurotin acid (2) to pleurotin (1).