1129490-51-2

Basic information

• Product Name: 6-(4-aminophenyl)-3-(1,2-O-isopropylidene-D-ribo-tetritol-1-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
• Synonyms: 6-(4-aminophenyl)-3-(1,2-O-isopropylidene-D-ribo-tetritol-1-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
• CAS NO: 1129490-51-2
• Molecular Weight: 377.424
• Mol File: 1129490-51-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(4-aminophenyl)-3-(1,2-O-isopropylidene-D-ribo-tetritol-1-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-aminophenyl)-3-(1,2-O-isopropylidene-D-ribo-tetritol-1-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole(1129490-51-2)
• EPA Substance Registry System: 6-(4-aminophenyl)-3-(1,2-O-isopropylidene-D-ribo-tetritol-1-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole(1129490-51-2)

Safety Data

• Hazardous Substances Data: 1129490-51-2(Hazardous Substances Data)

Upstream product

• 150-13-0 4-amino-benzoic acid 

Downstream Products

• 1129490-59-0 6-(4-aminophenyl)-3-(D-ribo-tetritol-1-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1141802-48-3 N-{4-[3-(1,2-O-isopropylidene-D-ribotetritol-1-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]phenyl}-4-nitrobenzenesulfonamide 
• 1141802-61-0 C₂₃H₂₂FN₅O₅S 
• 1141802-51-8 N-{4-[3-(1,2-O-isopropylidene-D-ribotetritol-1-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]phenyl}-4-methylbenzenesulfonamide 
• 1141802-45-0 N-{4-[3-(1,2-O-isopropylidene-D-ribotetritol-1-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]phenyl}-4-chlorobenzenesulfonamide 
• 1141802-54-1 N-{4-[3-(1,2-O-isopropylidene-D-ribotetritol-1-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]phenyl}furan-3-sulfonamide 
• 1141802-59-6 C₂₁H₂₁N₅O₅S₂ 
• 1141802-57-4 C₂₁H₂₁N₅O₆S 

Relevant articles and documents

Microwave-assisted synthesis and anti-HIV activity of new acyclic C-nucleosides of 3-(D-ribo-tetritol-1-yl)-5-mercapto-1,2,4-triazoles. Part 1

Microwave-assisted synthesis of novel acyclic C-nucleosides of 6-alkyl/aryl-3-(1,2-O-isopropylidene-D-ribo-tetritol-1-yl)[1,2,4]triazolo[3,4-b] [1,3,4]thiadiazoles (5-12) and the 6-aryl-thiomethyl analogues 25-27 has been described. Deblocking of 5-12 and 25-27 afforded the free acyclic C-nucleosides 13-20, and 28-30, respectively. All of the synthesized compounds showed no inhibition against HIV-1 and HIV-2 replication in MT-4 cells. However, 6-(3,4-dichlorophenyl)-3-(1,2-O-isopropylidene-D-ribo-tetritol-1-yl)-7H-1,2, 4-triazolo[3,4-b][1,3,4]thiadiazole (6) is a potent inhibitor, in vitro, of the replication of HIV-2. These results suggest that compound 6 should be considered as a new lead in the development of antiviral agent. Copyright Taylor & Francis Group, LLC.