112952-80-4

Upstream product

• 7536-55-2 N-tert-butyloxycarbonylasparagine 
• 1080-06-4 L-Tyr-OMe 
• 4587-33-1 N-(tert-butyloxycarbonyl)-L-asparagine p-nitrophenyl ester 

Downstream Products

• 96573-54-5 Boc-Asn-Tyr-N₂H₃ 
• 175729-34-7 (S)-2-((S)-3-Carbamoyl-2-{[3-(3-chloro-propoxy)-naphthalene-2-carbonyl]-amino}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 110433-95-9 Boc-Asn-Tyr-N₃ 
• 112952-81-5 Boc-Asn-Tyr-Lys(Z)-OBzl 
• 112952-83-7 H-Asn-Tyr-Lys(Z)-OBzl*TFA 

Relevant academic research and scientific papers

Immobilized Aspergillus Oryzae Protease Catalyzed Formation of Peptide Bonds in Organic Solvent

Immobilized Aspergillus oryzae protease (AOP) catalyzed the formation of peptide bonds between N-protected amino acids and amino acid esters or amides in ethyl acetate. The influences of pH and reaction time on the coupling of Boc-L-Tyr and Gly-NH2/

Synthesis and activity of conformationally-constrained macrocyclic norstatine-based inhibitors of HIV protease

Two diastereomers of a macrocyclic hydroxyamide (norstatine-based) peptide, having an 18-membered ring system, have been synthesized as HIV protease inhibitors. The (R)-diastereomer (IC50 19 nM) was ~17-fold weaker than an acyclic analog, but had comparable or better antiviral activity, suggesting improved cell penetration properties and/or resistance to cellular enzymes for the macrocyclic inhibitor.