1129528-26-2Relevant academic research and scientific papers
Synthesis of 2′-([1,2,3]triazol-1-yl)-2′-deoxyadenosines
O'Mahony, Gavin,Svensson, Sara,Sundgren, Andreas,Grotli, Morten
, p. 449 - 459 (2008/09/20)
A reliable and efficient protocol for the synthesis of 2′-([1,2,3] triazol-1-yl)-2′-deoxyadenosine derivatives from vidarabine is presented. Vidarabine was converted to 2′-azido-2′-deoxy-3′,5-O- (tetraisopropyldisiloxane-1,3-diyl)-adenosine. This azide was used as the starting material for the CuI-catalyzed parallel synthesis of 1,2,3-triazoles using a variety of alkynes. The reactions proceeded in good yield and gave almost exclusively the 1,4-disubstituted 1,2,3-triazoles. Copyright Taylor & Francis Group, LLC.
