112953-12-5

Basic information

• Product Name: 6-deoxyilludin M
• Synonyms: 6-deoxyilludin M
• CAS NO: 112953-12-5
• Molecular Formula: C15H20O2
• Molecular Weight: 232.3181
• Mol File: 112953-12-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 394.5°C at 760 mmHg
• Flash Point: 168.5°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 7.38E-08mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 6-deoxyilludin M(CAS DataBase Reference)
• NIST Chemistry Reference: 6-deoxyilludin M(112953-12-5)
• EPA Substance Registry System: 6-deoxyilludin M(112953-12-5)

Safety Data

• Hazardous Substances Data: 112953-12-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H20O2/c1-9-10-7-13(2,3)8-11(10)12(16)14(4,17)15(9)5-6-15/h8,17H,5-7H2,1-4H3/t14-/m0/s1

Upstream product

• 1146-04-9 illudin M 

Relevant articles and documents

Structure-Activity Relationships of Illudins: Analogs with Improved Therapeutic Index

Illudin S and M are extremely toxic sesquiterpenes produced by Omphalotus illudens.At low pH they behave as bifunctional alkylating agents, but at physiological pH they do not react with oxygen or nitrogen nucleophiles.Illudins react spontaneously with sulfur nucleophiles, gluthathione or cysteine, at or slightly below pH 7, and toxicity to HL 60 cells can be modulated by altering glutathione levels in cells.Analogs of illudin M, e.g. the deoxy and, particularly, the dehydro derivatives, are less reactive to thiols and correspondingly less toxic to HL 60 cells than the parent compound.Dehydroilludin M has been found to be quite effective at inhibiting tumor growth in vivo at doses well tolerated at athymic nude mice.