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112953-12-5

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112953-12-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 112953-12-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,9,5 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 112953-12:
(8*1)+(7*1)+(6*2)+(5*9)+(4*5)+(3*3)+(2*1)+(1*2)=105
105 % 10 = 5
So 112953-12-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H20O2/c1-9-10-7-13(2,3)8-11(10)12(16)14(4,17)15(9)5-6-15/h8,17H,5-7H2,1-4H3/t14-/m0/s1

112953-12-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Deoxyilludin M

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:112953-12-5 SDS

112953-12-5Upstream product

112953-12-5Downstream Products

112953-12-5Relevant articles and documents

Structure-Activity Relationships of Illudins: Analogs with Improved Therapeutic Index

McMorris, Trevor C.,Kelner, Michael J.,Wang, Wen,Estes, Leita A.,Montoya, Mark A.,Taetle, Raymond

, p. 6876 - 6883 (2007/10/02)

Illudin S and M are extremely toxic sesquiterpenes produced by Omphalotus illudens.At low pH they behave as bifunctional alkylating agents, but at physiological pH they do not react with oxygen or nitrogen nucleophiles.Illudins react spontaneously with sulfur nucleophiles, gluthathione or cysteine, at or slightly below pH 7, and toxicity to HL 60 cells can be modulated by altering glutathione levels in cells.Analogs of illudin M, e.g. the deoxy and, particularly, the dehydro derivatives, are less reactive to thiols and correspondingly less toxic to HL 60 cells than the parent compound.Dehydroilludin M has been found to be quite effective at inhibiting tumor growth in vivo at doses well tolerated at athymic nude mice.

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