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1129540-77-7

4-(3-morpholino-1H-1,2,4-triazol-1-yl)aniline is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1129540-77-7 Structure

  • Basic information

    1. Product Name: 4-(3-morpholino-1H-1,2,4-triazol-1-yl)aniline
    2. Synonyms:
    3. CAS NO:1129540-77-7
    4. Molecular Formula:
    5. Molecular Weight: 245.284
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1129540-77-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(3-morpholino-1H-1,2,4-triazol-1-yl)aniline(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(3-morpholino-1H-1,2,4-triazol-1-yl)aniline(1129540-77-7)
    11. EPA Substance Registry System: 4-(3-morpholino-1H-1,2,4-triazol-1-yl)aniline(1129540-77-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1129540-77-7(Hazardous Substances Data)

1129540-77-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1129540-77-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,2,9,5,4 and 0 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1129540-77:
(9*1)+(8*1)+(7*2)+(6*9)+(5*5)+(4*4)+(3*0)+(2*7)+(1*7)=147
147 % 10 = 7
So 1129540-77-7 is a valid CAS Registry Number.

1129540-77-7Relevant articles and documents

Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors

Kamenecka, Ted,Jiang, Rong,Song, Xinyi,Duckett, Derek,Chen, Weimin,Ling, Yuan Yuan,Habel, Jeff,Laughlin, John D.,Chambers, Jeremy,Figuera-Losada, Mariana,Cameron, Michael D.,Lin, Li,Ruiz, Claudia H.,LoGrasso, Philip V.

experimental part, p. 419 - 431 (2010/06/11)

Given the significant body of data supporting an essential role for c-jun-N-terminal kinase (JNK) in neurodegenerative disorders, we set out to develop highly selective JNK inhibitors with good cell potency and good brain penetration properties. The structure-activity relationships (SAR) around a series of aminopyrimidines were evaluated utilizing biochemical and cell-based assays to measure JNK inhibition and brain penetration in mice. Microsomal stability in three species, P450 inhibition, inhibition of generation of reactive oxygen species (ROS), and pharmacokinetics in rats were also measured. Compounds 9g, 9i, 9j, and 9l had greater than 135-fold selectivity over p38, and cell-based IC50 values 50 = 0.8 nM for inhibition of ROS and had good pharmacokinetic properties in rats along with a brain-to-plasma ratio of 0.75. These results suggest that biaryl substituted aminopyrimidines represented by compound 9l may serve as the first small molecule inhibitors to test efficacy of JNK inhibitors in neurodegenerative disorders. 2009 American Chemical Society.

SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS

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Page/Page column 128; 129, (2009/04/25)

The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.

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