1129683-92-6

Basic information

• Product Name: phenyl 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate
• Synonyms: phenyl 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate
• CAS NO: 1129683-92-6
• Molecular Weight: 363.373
• Mol File: 1129683-92-6.mol

Chemical Properties

• CAS DataBase Reference: phenyl 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate(1129683-92-6)
• EPA Substance Registry System: phenyl 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate(1129683-92-6)

Safety Data

• Hazardous Substances Data: 1129683-92-6(Hazardous Substances Data)

Upstream product

• 284462-37-9 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide 
• 1885-14-9 phenyl chloroformate 

Downstream Products

• 284461-73-0 sorafenib 

Relevant articles and documents

Process for the Preparation of a RAF Kinase Inhibitor and Intermediates for Use in the Process

There is provided a process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A) wherein R′ is selected from the group consisting of hydrogen, —C(O)OA, —C(O)CX3, —C(O)NH2, —C(O)—NHOH or There is also provided intermediate compounds of general formula (A), N-methyl-4-(4-ureidophenoxy)picolinamide, 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate derivative and N-methyl-4-(4-(2,2,2-trihaloacetamido)phenoxy)picolinamide, processes for their preparation and their use in the preparation of sorafenib.

PROCESS FOR THE PREPARATION OF A RAF KINASE INHIBITOR AND INTERMEDIATES FOR USE IN THE PROCESS

There is provided a process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A), wherein R' is selected from the group consisting of hydrogen, -C(O)OA, -C(O)CX3, - OH C(O)NH2, -C(O)-NHOH or (a). There is also provided intermediate compounds of general formula (A), N-methyl-4-(4-ureidophenoxy)picolinamide, 4-(2- (methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate derivative and N-methyl-4-(4-(2,2,2- trihaloacetamido)phenoxy)picolinamide, processes for their preparation and their use in the preparation of sorafenib.