112978-26-4Relevant academic research and scientific papers
REGIO- AND DIASTEREOSELECTIVITY IN ALDOL REACTIONS OF CYCLOPENT-2-ENONE, 2-(5H)FURANONE AND THEIR DERIVED TRIMETHYLSILYLOXYDIENES
Brown, David W.,Campbell, Malcolm M.,Taylor, Anthony P.,Zhang, Xiao-an
, p. 985 - 988 (2007/10/02)
Differences in erythro/threo-selectivity were assessed for aldol condensations of aldehydes with the lithium salts of cyclopent-2-enone, 2-(5H)furanone, and for Lewis acid catalysed condensation with the derived trimethylsilyloxydienes.
DIASTEREOSELECTIVITY IN THE DIRECTED ALDOL CONDENSATION OF 2-TRIMETHYLSILOXYFURAN WITH ALDEHYDES. A STEREODIVERGENT ROUTE TO THREO AND ERYTHRO δ-HYDROXY-γ-LACTONES
Jefford, Charles W.,Jaggi, Danielle,Boukouvalas, John
, p. 4037 - 4040 (2007/10/02)
Threo and erythro-δ-hydroxy-4a,β-unsaturated γ-lactones are obtained with useful diastereoselection by condensing 2-trimethylsiloxyfuran and aldehydes by variying the reaction conditions.A stereomechanistic rationale is presented together with a practical two-step synthesis of the threo and erythro 5-hydroxy-4-decanolides (L-factors).
