112978-58-2

Upstream product

• 112852-90-1 ((1S,2S,3S,5R)-2-Methoxymethyl-6,6-dimethyl-bicyclo[3.1.1]hept-3-yl)-dimethyl-silanol 
• 112852-89-8 ((1S,2S,3S,5R)-2-Methoxymethyl-6,6-dimethyl-bicyclo[3.1.1]hept-3-yl)-dimethyl-(1-propyl-but-3-enyloxy)-silane 

Relevant academic research and scientific papers

C-CENTRED OPTICALLY ACTIVE ORGANOSILANES,1. SYNTHESIS OF NEW SILYLATED CHIRAL AUXILIARIES.

Different silylating reagents with an optically active ligand bonded to the silicon centre have been synthesized starting from (1R)(-)myrtenal.The key step of the synthesis is the stereocontrolled 1,4 addition of phenyldimethylsilyl-cuprate to the α,β unsaturated aldehyde.

C-CENTRED OPTICALLY ACTIVE ORGANOSILANES,2. APPLICATION TO ENANTIOSELECTIVE ALLYLATION OF CARBONYL COMPOUNDS.

C-Centred optically active allylsilanes react with carbonyl compounds in presence of Lewis acids to give the corresponding homoallyl alcohols with ee varying from 21 to 56percent.The role of the Lewis acid is crucial for a correct development of the reaction; different procedures are tested and the results compared.