112980-37-7Relevant academic research and scientific papers
ALUMINA-MEDIATED CONDENSATION. A SIMPLE SYNTHESIS OF AURONES
Varma, Rajender S.,Varma, Manju
, p. 5937 - 5940 (1992)
A simple and high yielding synthesis of aurones (2-phenylmethylene-3(2H)-benzofuranones) is described which occurs under mild conditions on alumina surface using readily available benzofuranones and arylaldehydes.Key Words: Aurones; 2-Phenylmethylene-3(2H)-benzofuranones; Solid Surface; Alumina
Preparative and Regiochemical Aspects of the Palladium-Catalyzed Carbonylative Coupling of 2-Hydroxyaryl Iodides with Ethynylarenes
Ciattini, Pier Giuseppe,Morera, Enrico,Ortar, Giorgio,Rossi, Sabina Strano
, p. 6449 - 6456 (1991)
The title reaction has been conveniently carried out in DMF at 60 deg C under 1 atm CO pressure using DBU as the base and Pd(OAc)2(DPPF)2 as the catalyst to afford generally mixtures of flavones 4 and aurones 5 in varying yields, depending on the substituents in the both reactants.Factors controlling the regioselectivity for 4 or 5 formation in this and in similar, previously reported, coupling procedures have been examined.
THERAPEUTIC AURONES
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Page/Page column 72; 73, (2017/11/10)
Substituted aurones were found to have antitrypanosomal, antifungal and immunomodulatory activity. The invention provides novel aurone compounds, pharmaceutical compositions, and methods encompassing medical and veterinary applications.
