1130-89-8Relevant academic research and scientific papers
Facile, regioselective oxidative selenocyanation of: N -aryl enaminones under transition-metal-free conditions
Sorabad, Ganesh Shivayogappa,Maddani, Mahagundappa Rachappa
, p. 2222 - 2227 (2020)
A direct and straightforward approach for the regioselective selenocyanation of N-aryl enaminones through sp2 C-H functionalization has been realized at room temperature. In this study, KSeCN as the selenocyanate reagent and K2S2O8 as the oxidizing agent are employed under transition-metal-free conditions. The present methodology was also applied for the synthesis of selenocyanated chromones, indoles and anilines in good to excellent yields.
Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities
Guan, Qi,Han, Chunming,Zuo, Daiying,Zhai, Min'An,Li, Zengqiang,Zhang, Qian,Zhai, Yanpeng,Jiang, Xuewei,Bao, Kai,Wu, Yingliang,Zhang, Weige
, p. 306 - 315 (2014)
A series of novel benzimidazole carbamates bearing indole moieties with sulphur or selenium atoms connecting the aromatic rings were synthesised and evaluated for their antiproliferative activities against three human cancer cell lines (SGC-7901, A-549 and HT-1080) using an MTT assay. Compounds 10a, 10b, 7a, 7b and 7f showed significant activities against these cell lines. The most potent compound in this series, 10a, was selected to investigate its antitumour mechanism. In addition, molecular docking studies suggested that compound 10a interacts very closely with the nocodazole docking pose through hydrogen bonds at the colchicine binding site of tubulin.
Triselenium dicyanide from malononitrile and selenium dioxide. One-pot synthesis of selenocyanates
Kachanov, Andrey V.,Slabko, Oleg Yu.,Baranova, Olga V.,Shilova, Evgenia V.,Kaminskii, Vladimir A.
, p. 4461 - 4463 (2007/10/03)
Triselenium dicyanide is formed by the interaction of malononitrile and selenium dioxide in dimethylsulfoxide or dimethylformamide. Addition of aromatic amines, indoles and some active methylene compounds to this reaction mixture gives the corresponding s
A facile CAN-mediated synthesis of selenocyanates from arylalkenes and heteroarenes
Nair, Vijay,Augustine, Anu,George, Tesmol G.
, p. 2363 - 2366 (2007/10/03)
Selenocyanation of styrenes and indoles mediated by cerium(IV) ammonium nitrate (CAN) afforded the corresponding selenocyanates in moderate to good yields. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
