1130161-07-7Relevant academic research and scientific papers
Amide derivatives of ethacrynic acid: Synthesis and evaluation as antagonists of Wnt/β-catenin signaling and CLL cell survival
Jin, Guangyi,Lu, Desheng,Yao, Shiyin,Wu, Christina C.N.,Liu, Jerry X.,Carson, Dennis A.,Cottam, Howard B.
experimental part, p. 606 - 609 (2009/09/06)
A series of amides of ethacrynic acid was prepared and evaluated for their ability to inhibit Wnt signaling and decrease the survival of CLL cells. Several of the most potent derivatives were active in the low micromolar range. Reduction of the α,β-unsatu
