113018-68-1Relevant academic research and scientific papers
Synthesis of (+/-)--9-halogeno-2-methyl-1,2,3,4,4a,5,6,10b,11,12,12a-dodecahydronaphthoisoquinolines
Patrick, Graham L.
, p. 1273 - 1280 (2007/10/02)
Treatment of 5-(2-arylethyl)-1,2,3,4,5,6,7,8-octahydroisoquinolines with 48percent HBr resulted in isomerisation of the double bond and subsequent cyclisation at position 6 of the octahydroisoquinoline ring system to give (+/-)--9-halogeno-2-methyl-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho2,1-f>isoquinolines.The products obtained represent novel analogues of aza-D-homoestranes.No reaction was observed with the corresponding 5,5-disubstituted octahydroisoquinolines.An X-ray crystallographic study of compound 10 (X = Br) is described.
Intramolecular Alkylations of Aromatic Compounds, XVIII: Synthesis of 3,4-Dihydro-1'-methylspiro
Reimann, Eberhard,Speckbacher, Johann,Lotter, Hermann
, p. 385 - 393 (2007/10/02)
Refluxing the tetrahydroyridines 10 in hydrobromic acid gives the title compounds 12 stereoselectively.Their structures and configurations were confirmed by NMR spectroscopy and X-ray analysis.The tetrahydropyridines 10 were prepared from the pyridinecarbonitriles 5 and Grignard reagents 6 by standard methods.
