1130206-86-8

Basic information

• Product Name: 4,4'-bis[3-(1-methylpyrrol-2-yl)methyl-1,2,4-triazolin-5-on-4-yl]diphenylmethane
• Synonyms: 4,4'-bis[3-(1-methylpyrrol-2-yl)methyl-1,2,4-triazolin-5-on-4-yl]diphenylmethane
• CAS NO: 1130206-86-8
• Molecular Weight: 520.594
• Mol File: 1130206-86-8.mol

Chemical Properties

• CAS DataBase Reference: 4,4'-bis[3-(1-methylpyrrol-2-yl)methyl-1,2,4-triazolin-5-on-4-yl]diphenylmethane(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-bis[3-(1-methylpyrrol-2-yl)methyl-1,2,4-triazolin-5-on-4-yl]diphenylmethane(1130206-86-8)
• EPA Substance Registry System: 4,4'-bis[3-(1-methylpyrrol-2-yl)methyl-1,2,4-triazolin-5-on-4-yl]diphenylmethane(1130206-86-8)

Safety Data

• Hazardous Substances Data: 1130206-86-8(Hazardous Substances Data)

Upstream product

• 1130206-81-3 4,4'-bis[1-(1-methylpyrrole-2-yl)acetyl-semicarbazide]diphenylmethane 
• 158144-17-3 (1-methyl-pyrrol-2-yl)acetic acid hydrazide 
• 101-68-8 di(4-isocyanatophenyl)methane 

Relevant articles and documents

Anticancer screening and structure activity relationship study of some semicarbazides and 1,2,4-Triazolin-5-ones

In this paper some semicarbazide and 1,2,4-triazolin-5-one derivatives are evaluated in vitro for their anticancer activity towards human tumour cell line: ovary (TOV 112D), lung (A 549), breast (T47D) and uterus (Hela). Compounds 2-4 have been found to s

Antioxidant evaluation of some semicarbazide, 1,2,4-triazolone and pyrazolone derivatives

1,2,4-Triazoles, pyrazoles and semicarbazides possessing heterocyclic ring 1-14 were synthesized as compounds with interesting pharmacological profiles. All were investigated in vitro for their antioxidant activity. Some compounds showed significant effect in the above assay. The most promising was a group of pyrazolone. The effect was dependent mainly on the substituent on the amide group. It was found that compounds 8 and 10 showed the highest antioxidant capacity comparable with the widely used reference, antioxidant 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid (Trolox).

Synthesis and antinociceptive activity of 4,4'-bis(1-substituted- semicarbazidyl)diphenylmethane and 4,4-bis(5-substituted-2,4-dihydro-3-oxo-3H-1, 2,4- triazol-4-yl)diphenylmethane derivatives

In the reaction of 4,4'-diphenylmethane diiso-cyanate with carboxylic acid hydrazides, 4,4'-bis(1- substituted-semicarbazidyl)diphenylmethane derivatives were obtained. Depending on their chemical nature, cyclization of these compounds in alkaline medium led to the formation of two groups of compounds: bis(2,4-dihy- dro-3H-1,2,4-triazol-3-one) derivatives or carboxylic acids. The pharmacological effects of the selected compounds on the central nervous system in mice were investigated. Strong antinociceptive properties of some derivatives, at a wide range of doses, were observed. Springer-Verlag 2010.

Synthesis, experimental and theoretical investigations of some new 4,4′-bis(3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)diphenylmethane derivatives

The 4,4′-bis(3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)diphenylmethane derivatives 3 were synthesized in the cyclization reaction of semicarbazide derivatives 2 in alkaline solution. The synthesized compounds were characterized by elemental an