113021-30-0

Basic information

• Product Name: 2-Iodo-1-indanone
• Synonyms: 2-IODO-1-INDANONE;2,3-Dihydro-2-iodo-1H-inden-1-one;2-Iodoindanone;2-Iodo-1H-indene-3(2H)-one;2-Iodo-2,3-dihydro-1H-indene-1-one;2-Iodoindan-1-one;2-iodo-2,3-dihydro-1H-inden-1-one
• CAS NO: 113021-30-0
• Molecular Formula: C₉H₇IO
• Molecular Weight: 258.06
• Mol File: 113021-30-0.mol
• Article Data: 19

Chemical Properties

• Melting Point: 67-69 °C
• Boiling Point: 309.68 °C at 760 mmHg
• Flash Point: 141.09 °C
• Appearance: /
• Density: 1.87
• Vapor Pressure: 0.00063mmHg at 25°C
• Refractive Index: 1.671
• CAS DataBase Reference: 2-Iodo-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-1-indanone(113021-30-0)
• EPA Substance Registry System: 2-Iodo-1-indanone(113021-30-0)

Safety Data

• Hazardous Substances Data: 113021-30-0(Hazardous Substances Data)

Usage

General Description

2-Iodo-1-indanone is a chemical compound with the formula C9H7IO. It is a pale yellow solid that is used as a reagent in organic synthesis. It is commonly used in the preparation of various pharmaceuticals and as an intermediate in the synthesis of other chemical compounds. 2-Iodo-1-indanone is also utilized in the manufacturing of agrochemicals and dyes. Additionally, it has been studied for its potential biological activities, including its ability to inhibit the growth of certain cancer cells. Due to its versatile reactivity and wide range of applications, 2-Iodo-1-indanone is an important compound in the field of organic chemistry and drug discovery.

InChI:InChI=1/C9H7IO/c10-8-5-6-3-1-2-4-7(6)9(8)11/h1-4,8H,5H2

Upstream product

• 95-13-6 1-indene 
• 83-33-0 inden-1-one 
• 155060-13-2 4-Nitro-benzenesulfonic acid 1-oxo-indan-2-yl ester 
• 19455-83-5 1H-inden-3-yl acetate 

Downstream Products

• 480-90-0 1H-inden-1-one 
• 83-33-0 inden-1-one 

Relevant articles and documents

The Effect of the Carbonyl Group, Phenyl Ring, and Ring Size of α-Iodo Cycloketones on the Nature of the Photochemical Carbon-Iodine Bond Cleavage

UV irradiation of 2-iodo-3,4-dihydro-1(2H)-naphthalenone and 2-iodo-1-indanone has been found to involve competing radical and ionic photoprocesses.The carbonyl group, phenyl ring and ring size of cycloketones have an influence on the nature of the photochemical carbon-iodine bond cleavage.

IBX/I2-mediated oxidation of alkenes and alkynes in water: a facile synthesis of α-iodoketones

The conversion of alkenes into α-iodoketones has been achieved in good yields and with high regioselectivity by means of iodohydrin formation and subsequent oxidation with 2-iodoxybenzoic acid (IBX) under mild conditions. Aromatic alkynes are also convert

Iodination of organic compounds with elemental iodine in the presence of hydrogen peroxide in ionic liquid media

Iodo-transformations using the reagent system I2/H 2O2 were studied in the water miscible ionic liquid (IL) 1-butyl-3-methyl imidazolium tetrafluoroborate (bmimBF4) and in water immiscible IL, 1-butyl-3-methyl i

IBX works efficiently under solvent free conditions in ball milling

IBX (2-iodoxybenzoic acid), discovered in 1893, is an oxidant in synthetic chemistry whose extensive use is impeded by its explosiveness at high temperature and poor solubility in common organic solvents except DMSO. Since the discovery of Dess-Martin Periodinane in 1983, several modified IBX systems have been reported. However, under ball milling conditions, IBX works efficiently with various organic functionalities at ambient temperature under solvent free conditions. Also, the waste IBA (2-iodosobenzoic acid) produced from the reactions was in situ oxidized to IBX in the following step using oxone and thus reused for multiple cycles by conserving its efficiency (only ～6% loss after 15 cycles). This work describes an overview of a highly economical synthetic methodology which overcomes the problems of using IBX, efficiently in gram scale and in a non-explosive way. This journal is the Partner Organisations 2014.

An expedient protocol for conversion of olefins to α-bromo/iodoketones using IBX and NBS/NIS

A variety of olefins have been shown to undergo conversion to the corresponding α-bromo/iodoketones when reacted with NBS/NIS and IBX in DMSO at room temperature. While the reaction is found to occur rapidly with e-rich arylolefins leading to the corresponding haloketones in 65-95% yields in 0.3-3.0 h, those containing e-withdrawing groups are found to yield diketones concomitantly, such that the latter are the exclusive products over extended duration of the reactions.