1130835-15-2Relevant academic research and scientific papers
Peptide-Chain Elongation Using Unprotected Amino Acids in a Micro-Flow Reactor
Fuse, Shinichiro,Masuda, Koshiro,Otake, Yuma,Nakamura, Hiroyuki
, p. 15091 - 15097 (2019/11/13)
Conventional peptide synthesis requires a deprotection step after each amidation step, which decreases synthetic efficiency. Therefore, peptide synthesis using unprotected amino acids is considered an ideal approach. Here, we report peptide chain elongati
An efficient synthetic method of N-protected dipeptide acids using amino acid calcium carboxylates in an organic solvent
Hashimoto, Chikao,Takeguchi, Kazunobu,Kodomari, Mitsuo
experimental part, p. 1427 - 1430 (2011/08/03)
The syntheses of N-protected dipeptide acids using alkaline earth metal (Mg, Ca, and Ba) carboxylates of an amino acid in organic solvents were investigated. It was found that amino acid calcium carboxylates are the most effective among the carboxylates of the amino acids tested for coupling with active esters of Boc-Ala-OH in organic solvents. The coupling of Boc-Ala-ONp or Boc-Ala-ONSu with amino acid calcium carboxylates in DMF gave the desired N-protected dipeptide acids in high yields (92-100%). Georg Thieme Verlag Stuttgart - New York.
