113085-89-5

Upstream product

• 66223-54-9 (E)-3-(m-tolyl)acrylaldehyde 
• 125616-92-4 [(2R,3R)-3-(3-methylphenyl)oxiran-2-yl]methanol 
• 93614-80-3 3-(3-methylphenyl)prop-2-en-1-al 

Relevant academic research and scientific papers

ORGANIC SALTS AND METHOD FOR PRODUCING CHIRAL ORGANIC COMPOUNDS

The invention relates to a method for producing chiral organic compounds by asymmetric catalysis, using ionic catalysts comprising a chiral catalyst anion. The claimed method is suitable for reactions which are carried out over cationic intermediate stages, such as iminium ions or acyl pyridinium ions. The invention enables the production of chiral compounds with high ee values, that until now could only be obtained by means of costly purification methods.

Asymmetric counteranion-directed catalysis for the epoxidation of enals

(Chemical Equation Presented) A new mode of chiral anion catalysis: A powerful chiral-counteranion strategy for catalytic asymmetric epoxidations using the newly discovered catalyst 1 has been applied to the epoxidation of α,β-unsaturated aldehydes together with tert-butyl hydroperoxide as the oxidant (see scheme). Remarkably, this system provides the corresponding epoxides in high diastereo- and enantioselectivity for both di- and trisubstituted enals.

Alkanophenones useful for treating allergies

Substituted alkanophenones of general formula STR1 in which R1 is unsubstituted or fluorinated lower alkyl, R2 is hydrogen, or unsubstituted or fluorinated lower alkyl or lower alkenyl, X is lower alkylene, oxy, thio or a direct bond, alk is lower alkylene, n is 1 or 2, R3 is phenyl that is unsubstituted or is substituted by unsubstituted or fluorinated lower alkyl, by etherified or esterified hydroxy, by unsubstituted or lower alkylated amino and/or by free, esterified or amidated carboxy, or is lower alkyl that is unsubstituted, substituted by fluoro and chloro or substituted by free esterified or amidated carboxy, R4 is free, esterified or amidated carboxy or 5-tetrazolyl, and R5 is hydrogen or lower alkyl, have leucotriene-antagonistic properties and can be used as anti-allergic active ingredients in medicaments.

EPOXIDATION OF trans-3-ARYLPROPENALS BY tert-BUTYL HYDROPEROXIDE

The products and the kinetics of the epoxidation of trans-3-arylpropenals with tert-butyl hydrogen peroxide in an alkaline medium were studied.The epoxidation rate increases with increase in the electron-withdrawing characteristics of the substituents in the aryl fragment of cinnamaldehydes.