1130969-90-2

Basic information

• Product Name: ethyl 2,6-bis(3-chlorophenyl)-1-(4-chlorophenyl)-4-(4-chlorophenylamino)-1,2,5,6-tetrahydropyridine-3-carboxylate
• Synonyms: ethyl 2,6-bis(3-chlorophenyl)-1-(4-chlorophenyl)-4-(4-chlorophenylamino)-1,2,5,6-tetrahydropyridine-3-carboxylate
• CAS NO: 1130969-90-2
• Molecular Weight: 612.383
• Mol File: 1130969-90-2.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2,6-bis(3-chlorophenyl)-1-(4-chlorophenyl)-4-(4-chlorophenylamino)-1,2,5,6-tetrahydropyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,6-bis(3-chlorophenyl)-1-(4-chlorophenyl)-4-(4-chlorophenylamino)-1,2,5,6-tetrahydropyridine-3-carboxylate(1130969-90-2)
• EPA Substance Registry System: ethyl 2,6-bis(3-chlorophenyl)-1-(4-chlorophenyl)-4-(4-chlorophenylamino)-1,2,5,6-tetrahydropyridine-3-carboxylate(1130969-90-2)

Safety Data

• Hazardous Substances Data: 1130969-90-2(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 106-47-8 4-chloro-aniline 
• 587-04-2 m-Chlorobenzaldehyde 

Relevant articles and documents

One-pot three-component synthesis of highly substituted piperidines using 1-methyl-2-oxopyrrolidinium hydrogen sulfate

1-Methyl-2-oxopyrrolidinium hydrogen sulfate ([Hpyro][HSO4]) is used as an ionic liquid catalyst for the one-pot three-component synthesis of highly substituted piperidines from aromatic aldehydes, anilines and β-ketoesters in refluxing ethanol

Multicomponent synthesis of highly functionalized piperidines using sulfamic acid as a heterogeneous and cost effective catalyst

Sulfamic acid has been found as an efficient and cost effective catalyst for one pot multicomponent synthesis of some new densely functionalized piperidine derivatives using amines, aldehydes and β-keto esters. The meritorious aspects of this novel protocol are atom economic process, heterogeneous and easily accessible catalyst, good to excellent yield, convenient work up and eco-friendly route.

Fe(NO3)3·9H2O as efficient catalyst for one-pot synthesis of highly functionalized piperidines

Fe(NO3)3·9H2O is used as an efficient and effective catalyst for the one-pot three-component synthesis of highly functionalized piperidines from aromatic aldehydes, anilines and β-ketoesters in ethanol at ambient temperature. This procedure includes some important aspects like the easy work-up, no need to column chromatography, simple and readily available precursors, and good to high yields.

One-pot multicomponent synthesis of highly substituted piperidines using p-toluenesulfonic acid monohydrate as catalyst

β-Toluenesulfonic acid monohydrate (p-TsOH-H2O) is a highly effective and efficient catalyst for the one-pot multicomponent coupling of aldehydes, amines, and β-ketoesters in EtOH at ambient temperature to give highly functionalized piperidines in high yields. This one-pot reaction has some important advantages such as the easy workup procedure, simple and readily available precursors, nontoxic and inexpensive catalyst, and good to high yields. Springer-Verlag 2011.

One-pot five-component synthesis of highly functionalized piperidines using oxalic acid dihydrate as a homogenous catalyst

An efficient green protocol is described for the preparation of highly functionalized piperidines via a one-pot five-component reaction between aromatic aldehydes, anilines and β-ketoesters in the presence of oxalic acid dihydrate as catalyst in ethanol at ambient temperature. The structure as well as the relative stereochemistry of these compounds was confirmed by single X-ray crystallographic analysis.

Cerium ammonium nitrate-catalyzed multicomponent reaction for efficient synthesis of functionalized tetrahydropyridines

A highly atom-economic one-pot synthesis of functionalized tetrahydropyridines by a multicomponent condensation reaction of β-keto ester, two equivalents of aromatic aldehyde, and two equivalents of amine in the presence of a catalytic amount of cerium ammonium nitrate (CAN) is reported. In this way, a series of pharmacologically interesting substituted piperidine derivatives were obtained in moderate to good yields at room temperature.

Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials

A highly atom economic one pot synthesis of tetrahydropyridines was achieved by l-proline/TFA catalysed multicomponent reaction of β-keto-esters, aromatic aldehydes and anilines. The synthesized compounds were screened against Plasmodium falciparum in vitro and one of them showed antimalarial activity with MIC as low as 0.09 μg/mL.