1131-92-6

Basic information

• Product Name: 2-(2,4-dichlorobenzyl)guanidine hydrochloride (1:1)
• CAS NO: 1131-92-6
• Molecular Formula: C₈H₁₀Cl₃N₃
• Molecular Weight: 254.5441
• Mol File: 1131-92-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 361.6°C at 760 mmHg
• Flash Point: 172.5°C
• Vapor Pressure: 2.05E-05mmHg at 25°C
• CAS DataBase Reference: 2-(2,4-dichlorobenzyl)guanidine hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-dichlorobenzyl)guanidine hydrochloride (1:1)(1131-92-6)
• EPA Substance Registry System: 2-(2,4-dichlorobenzyl)guanidine hydrochloride (1:1)(1131-92-6)

Safety Data

• Hazardous Substances Data: 1131-92-6(Hazardous Substances Data)

Usage

Purpose

Antiseptic and disinfectant

Common uses

Pharmaceutical and personal care products (mouthwash, throat sprays, skin cleansers)

Mechanism of action

Disrupts bacterial cell walls, leading to destruction

Effective against

Wide range of bacteria and fungi

Precaution

Can cause skin irritation and allergic reactions in some individuals

Relevant articles and documents

INHIBITION OF CELL PROLIFERATION

The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.