1131006-65-9Relevant academic research and scientific papers
Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
Cohen, Frederick,Alicke, Bruno,Elliott, Linda O.,Flygare, John A.,Goncharov, Tatiana,Keteltas, Stephen F.,Franklin, Matthew C.,Frankovitz, Stacy,Stephan, Jean-Philippe,Tsui, Vickie,Vucic, Domagoj,Wong, Harvey,Fairbrother, Wayne J.
experimental part, p. 1723 - 1730 (2010/02/28)
A series of IAP antagonists based on an azabicyclooctane scaffold was designed and synthesized. The most potent of these compounds, 14b, binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domain of c-IAP1 with Ki values of 14
