1131007-45-8

Basic information

• Product Name: 6-(trifluoroMethoxy)pyridin-2-aMine
• Synonyms: 6-(trifluoroMethoxy)pyridin-2-aMine
• CAS NO: 1131007-45-8
• Molecular Formula: C₆H₅F₃N₂O
• Molecular Weight: 178.1119096
• Mol File: 1131007-45-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 180.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.421±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.15±0.29(Predicted)
• CAS DataBase Reference: 6-(trifluoroMethoxy)pyridin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(trifluoroMethoxy)pyridin-2-aMine(1131007-45-8)
• EPA Substance Registry System: 6-(trifluoroMethoxy)pyridin-2-aMine(1131007-45-8)

Safety Data

• Hazardous Substances Data: 1131007-45-8(Hazardous Substances Data)

Usage

General Description

6-(trifluoroMethoxy)pyridin-2-aMine is a chemical compound with the molecular formula C7H6F3NO. It is an aromatic amine with a pyridine ring substituted with a trifluoromethoxy group at the 6-position. 6-(trifluoroMethoxy)pyridin-2-aMine is commonly used in the synthesis of various pharmaceuticals and agrochemicals due to its potential as a building block in organic chemistry. It is also used as a reagent in chemical reactions, particularly in the formation of carbon-carbon bonds. The trifluoromethoxy group imparts unique chemical and physical properties to the compound, making it valuable in various research and industrial applications.

Relevant articles and documents

A general approach to (trifluoromethoxy)pyridines: First X-ray structure determinations and quantum chemistry studies

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies. A general and efficient route to (trifluoromethoxy)pyridines is reported. Regioselective functionalization by organometallic methods afforded new and highly important building blocks for life-sciences-oriented research. The first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed and supported by in silico studies.