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1131041-72-9

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1131041-72-9 Usage

General Description

2-Amino-5-bromo-6-chloropyridin-3-ol is a chemical compound with the molecular formula C5H4BrClN2O. It is a heterocyclic organic compound with a pyridine ring substituted with amino, bromo, chloro, and hydroxyl functional groups. 2-AMino-5-broMo-6-chloropyridin-3-ol has potential applications in the pharmaceutical industry, particularly in the development of new drugs. Its unique structure and properties make it a valuable building block for the synthesis of various biologically active compounds. Additionally, it may also have uses in the field of agrochemicals and materials science. However, it is important to handle this compound with care and follow proper safety protocols due to its potential hazards.

Check Digit Verification of cas no

The CAS Registry Mumber 1131041-72-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,1,0,4 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1131041-72:
(9*1)+(8*1)+(7*3)+(6*1)+(5*0)+(4*4)+(3*1)+(2*7)+(1*2)=79
79 % 10 = 9
So 1131041-72-9 is a valid CAS Registry Number.
InChI:InChI=1S/C5H4BrClN2O/c6-2-1-3(10)5(8)9-4(2)7/h1,10H,(H2,8,9)

1131041-72-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-5-bromo-6-chloropyridin-3-ol

1.2 Other means of identification

Product number -
Other names 2-amino-5-bromo-6-chloro-3-pyridinol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1131041-72-9 SDS

1131041-72-9Downstream Products

1131041-72-9Relevant articles and documents

Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines

Lin, Hong,Yamashita, Dennis S.,Xie, Ren,Zeng, Jin,Wang, Wenyong,Leber, Jack,Safonov, Igor G.,Verma, Sharad,Li, Mei,LaFrance, Louis,Venslavsky, Joseph,Takata, Dennis,Luengo, Juan I.,Kahana, Jason A.,Zhang, Shuyun,Robell, Kimberly A.,Levy, Dana,Kumar, Rakesh,Choudhry, Anthony E.,Schaber, Michael,Lai, Zhihong,Brown, Barry S.,Donovan, Brian T.,Minthorn, Elisabeth A.,Brown, Kristin K.,Heerding, Dirk A.

scheme or table, p. 684 - 688 (2010/06/14)

The synthesis and evaluation of tetrasubstituted aminopyridines, bearing novel azaindazole hinge binders, as potent AKT inhibitors are described. Compound 14c was identified as a potent AKT inhibitor that demonstrated reduced CYP450 inhibition and an improved developability profile compared to those of previously described trisubstituted pyridines. It also displayed dose-dependent inhibition of both phosphorylation of GSK3β and tumor growth in a BT474 tumor xenograft model in mice.

INHIBITORS OF AKT ACTIVITY

-

Page/Page column 9; 37-38, (2009/04/25)

Invented are novel substituted pyridine compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

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