113105-92-3Relevant academic research and scientific papers
Synthesis of 9-Substituted-oxy Acridine and 1,2,3,4-Tetrahydroacridine Derivatives as Potential Biodynamic Agents
Asthana, Pratibha,Prasad, Mohan,Rastogi, Shri Nivas
, p. 330 - 334 (2007/10/02)
9-(3-Substituted-2-hydroxypropyloxy)acridines (5-11) and 9-(2-hydroxy-3-morpholinopropyloxy)-1,2,3,4-tetrahydroacridine (17) have been synthesised via the epoxy intermediates 9-(2,3-epoxypropyloxy)acridine (4) and the corresponding tetrahydroacridine (15).A few 9-(thiocyanato, phenylcarbamoyloxy and substituted amino)-tetrahydroacridines (21, 23 and 24-27) and 2,3-epoxypropyl N-phenylanthranilate (3) have also been prepared.Compounds 15, 17, 22, 24 and 26 show in vitro antiamoebic activity at 16 - 62.5 μg/ml dose while the standard drug metronidazole is found antiamoebic at 4 μg/ml.Compounds 25-27 exhibit local anaesthetic activity at 0.2percent concentration.
