113116-42-0Relevant articles and documents
Acid-catalyzed reaction of 2-hydroxycyclobutanone with benzylic alcohols
Martis, Alberto,Luridiana, Alberto,Frongia, Angelo,Arca, Massimiliano,Sarais, Giorgia,Aitken, David J.,Guillot, Regis,Secci, Francesco
, p. 10053 - 10063 (2017)
The acid-promoted syntheses of 2-(benzyloxy)cyclobutanones and bis(benzyloxy)dioxatricyclo decanes were achieved starting from 2-hydroxycyclobutanone and variously functionalized benzyl alcohols. The reaction sequences afforded the desired products in good to high yields and in a solvent-dependent chemoselective fashion.
Free radical cyclization approach to the hexahydrobenzofuran moiety of avermectins: a model study
Ardisson, J.,Ferezou, J. P.,Julia, M.,Li, Y.,Liu, L. W.,Pancrazi, A.
, p. 387 - 400 (2007/10/02)
Hexahydrobenzofurans were prepared through Bu3SnH radical cyclization of propargyloxy cyclohexanone precursors.Good results were obtained for monosubstituted acetylenic derivatives after conversion of the carbonyl group into the corresponding enol ether.U
Intramolecular Free Radical Cyclisations onto Enol Ethers. A General Synthesis of α-Alkyl-β-oxy- and α-Methylene-β-oxy-γ-butyrolactones
Begley, Michael J.,Landlow, Mark,Pattenden, Gerald
, p. 1095 - 1106 (2007/10/02)
Radical cyclisation of the enol ether bromoacetals (26), (28a-c), (29), and (37) in the presence of tributylstannane, produces precursors to the β-oxy-γ-butyrolactones (33), (34a-c), (35), and the α-methylene-β-oxy-γ-butyrolactone (39) in high overall yields.By contrast, treatment of (26) and (28a-b) with the cobalt(I) reagent derived from bis(dimethylglyoximato)(pyridine)cobalt(III) chloride (40), followed by oxidation of the intermediates (43) leads to the corresponding unsaturated β-oxy-γ-butyrolactones (42).