1131192-69-2Relevant academic research and scientific papers
A conceptually new approach to the asymmetric synthesis of 3-aryl and alkyl poly-substituted isoindolinones
Deniau, Eric,Couture, Axel,Grandclaudon, Pierre
experimental part, p. 2735 - 2740 (2009/04/07)
A conceptually new and efficient asymmetric synthesis of C-3 arylated or alkylated poly-substituted isoindolinones is reported. The key step is the diastereoselective reduction of an N-acylhydrazonium species derived from the previously assembled corresponding hydroxyl derivative bearing the (S)-2-methoxymethylpyrrolidine (SMP) auxiliary.
