113123-15-2Relevant academic research and scientific papers
Synthesis of 2,3,4,5-tetrasubstituted pyrroles from aromatic ketoximes using the TiCl4/Et3N reagent system
Periasamy, Mariappan,Srinivas, Gadthula,Seenivasaperumal, Muthu
, p. 270 - 272 (2007/10/03)
Aryl alkyl ketoximes react with the TiCl4/Et3N reagent to give 2,3,4,5-tetrasubstituted pyrroles in moderate to good yields (55-81%).
Reaction of Ketone Alkylhydrazones with Phosphorus Trichloride: a General Mild Route to Substituted Pyrroles
Baccolini, Graziano
, p. 1053 - 1056 (2007/10/02)
A new convinient and mild procedure for the synthesis of symmetrically and unsymmetrically substituted pyrroles is described.This one-pot synthesis consists of two different stages.The first stage, addition of PCl3 to an alkylhydrazone, is always carried out at room temperature.The second stage, addition of an enolizable ketone to the previous reaction mixture, is performed at room temperature, or at 80 deg C under reduced pressure.The results provide clear evidence that diazaphsphole derivatives being formed in the first stage are intermediates in this pyrrole synthesis.
Synthesis of Pyrroles under Mild Conditions using PCl3, Ketones, and Alkylhydrazines
Baccolini, Graziano,Sandali, Claudio
, p. 788 - 789 (2007/10/02)
A one-pot synthesis of symmetrical pyrroles was obtained by reaction of alkylhydrazones of enolizable ketones, PCl3, and subsequent addition of the same ketone.
