113124-09-7

Basic information

• Product Name: 3-Pyridinecarbonitrile,5,6-dimethyl-(9CI)
• Synonyms: 3-Pyridinecarbonitrile,5,6-dimethyl-(9CI);5,6-Dimethyl-nicotinonitrile;5,6-Dimethyl-3-Pyridincarbonitrile;5,6-dimethylpyridine-3-carbonitrile;5,6-Dimethyl-3-Pyridincarbonitrile(WX683521)
• CAS NO: 113124-09-7
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.165
• Product Categories: PYRIDINE
• Mol File: 113124-09-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 262.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.05±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.80±0.20(Predicted)
• CAS DataBase Reference: 3-Pyridinecarbonitrile,5,6-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonitrile,5,6-dimethyl-(9CI)(113124-09-7)
• EPA Substance Registry System: 3-Pyridinecarbonitrile,5,6-dimethyl-(9CI)(113124-09-7)

Safety Data

• Hazardous Substances Data: 113124-09-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 24, p. 351, 1987 DOI: 10.1002/jhet.5570240211

Upstream product

• 143193-92-4 sodium 2‐methyl‐3‐oxobut‐1‐en‐1‐olate 
• 72716-80-4 1,2-dihydro-5,6-dimethyl-2-oxo-3-pyridinecarbonitrile 
• 65176-93-4 2-chloro-5,6-dimethylpyridine-3-carbonitrile 
• 113124-06-4 2-bromo-5,6-dimethyl-3-pyridinecarbonitrile 

Downstream Products

• 757903-81-4 5,6-dimethylpyridine-3-carboxylic acid 
• 113124-10-0 5-carboxy-2,3-dimethylpyridinium chloride 
• 1375541-21-1 (S)-2′-oxo-1′,2′,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridine]-3-carboxylic acid 

Relevant articles and documents

Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides

A new series of 3-(3-pyridyl)acrylamides 16, 17, 19, and 26, and 5-(3-pyridyl)-2,4-pentadienamides 20-25 were prepared and evaluated for their antiallergic activity. Several of these compounds exhibited more potent inhibitory activities than the parent compounds 1a [(E)-N-[4 [4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamide] against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase. Particularly, 4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide (17p) showed an ED50 value of 3.3 mg/kg po in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, compound 17p (AL-3264) possessed a better balance of antiallergic properties due to inhibition of chemical mediator release, inhibition of 5-lipoxygenase, and antagonism of histamine.