1131608-22-4Relevant academic research and scientific papers
Discovery of 6-phenylimidazo[2,1-b]thiazole derivatives as a new type of FLT3 inhibitors
Lin, Xing-Dong,Yang, Hui-Wen,Ma, Shuang,Li, Wei-Wei,Zhang, Chun-Hui,Wang, Wen-Jing,Xiang, Rong,Li, Lin-Li,Yang, Sheng-Yong
supporting information, p. 4534 - 4538 (2015/10/12)
In this investigation, a series of 6-phenylimidazo[2,1-b]thiazole derivatives were synthesized. Structure-activity relationship (SAR) analysis of these compounds based on cellular assays led to the discovery of a number of compounds that showed potent act
Search for a novel SIRT1 activator: Structural modification of SRT1720 and biological evaluation
Matsuya, Yuji,Kobayashi, Yuta,Uchida, Sayumi,Itoh, Yukihiro,Sawada, Hideyuki,Suzuki, Takayoshi,Miyata, Naoki,Sugimoto, Kenji,Toyooka, Naoki
, p. 4907 - 4910 (2013/09/02)
Syntheses and biological evaluation of novel SRT1720 derivatives are described in search for new candidates of SIRT1 activator. Several parts of the SRT1720 structure, including piperazine moiety, quinoxaline ring on the amide group, and position of the amide function, were modified, and the assay results indicated that transfer of the ortho amide-substituent regarding to the imidazo[1,2-b]thiazole core onto the meta position resulted in improvement of SIRT1 activation ability. Modeling analyses of SRT1720 and the most potent derivative bound to model complex of SIRT1 with peptide substrate were also performed.
