1131735-94-8 Usage
General Description
4-(diisopropylcarbamoyl)-2-ethoxypyridin-3-ylboronic acid is a chemical compound with a boronic acid functional group and a pyridine ring. It is commonly used as a building block in organic synthesis and medicinal chemistry. The diisopropylcarbamoyl group serves as a protecting group for the boronic acid, allowing for manipulation and selective reactions in chemical synthesis. The ethoxy group on the pyridine ring also contributes to its reactivity and potential applications. 4-(diisopropylcarbaMoyl)-2-ethoxypyridin-3-ylboronic acid has potential use in the development of pharmaceuticals, agrochemicals, and materials science due to its unique structure and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 1131735-94-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,1,7,3 and 5 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1131735-94:
(9*1)+(8*1)+(7*3)+(6*1)+(5*7)+(4*3)+(3*5)+(2*9)+(1*4)=128
128 % 10 = 8
So 1131735-94-8 is a valid CAS Registry Number.
1131735-94-8Relevant articles and documents
The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: Lead optimization
Siu, Tony,Kumarasinghe, Sathyajith E.,Altman, Michael D.,Katcher, Matthew,Northrup, Alan,White, Catherine,Rosenstein, Craig,Mathur, Anjili,Xu, Lin,Chan, Grace,Bachman, Eric,Bouthillette, Melaney,Dinsmore, Christopher J.,Marshall, C. Gary,Young, Jonathan R.
, p. 1466 - 1471 (2014/03/21)
This communication discusses the discovery of novel reverse tricyclic pyridones as inhibitors of Janus kinase 2 (JAK2). By using a kinase cross screening approach coupled with molecular modeling, a unique inhibitor-water interaction was discovered to impart excellent broad kinase selectivity. Improvements in intrinsic potency were achieved by utilizing a rapid library approach, while targeted structural changes to lower lipophilicity led to improved rat pharmacokinetics. This multi-pronged approach led to the identification of 31, which demonstrated encouraging rat pharmacokinetics, in vivo potency, and excellent off-target kinase selectivity.
