113175-12-5Relevant academic research and scientific papers
MexAB-OprM-specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: Discovery and early strategies for lead optimization
Nakayama, Kiyoshi,Ishida, Yohei,Ohtsuka, Masami,Kawato, Haruko,Yoshida, Ken-Ichi,Yokomizo, Yoshihiro,Hosono, Shigeru,Ohta, Toshiharu,Hoshino, Kazuki,Ishida, Hiroko,Yoshida, Kumi,Renau, Thomas E.,Leger, Roger,Zhang, Jason Z.,Lee, Ving J.,Watkins, William J.
, p. 4201 - 4204 (2007/10/03)
The identification of a series of compounds that specifically inhibit efflux by the MexAB-OprM pump system in Pseudomonas aeruginosa is described. Synthesis and in vitro structure-activity relationships (SARs) are outlined. Early leads lacked activity in
